Castleman Disease

Wei Wang; L. Jeffrey Medeiros

doi:10.1016/j.path.2019.03.003

Castleman Disease

Wei Wang, L. Jeffrey Medeiros

Hematopathology

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Castleman disease (CD) is divided clinically into unicentric or multicentric type. Pathologically, CD is divided into hyaline-vascular and plasma cell variants. Unicentric CD is most common, about 75% of these cases are hyaline-vascular variant, and surgical excision is often curative. In contrast, there are a number of types of multicentric CD including HHV8-associated, idiopathic, and a subset of cases that arise in association with POEMS syndrome. Therapy is required for most patients with multicentric CD, but there is no consensus approach currently. As is evidence, the designation Castleman disease encompasses a heterogeneous group of diseases of varied pathogenesis and which require different therapies.

Original language	English (US)
Pages (from-to)	849-863
Number of pages	15
Journal	Surgical Pathology Clinics
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/j.path.2019.03.003
State	Published - Sep 2019

Keywords

Castleman disease
Human herpes virus type 8
Lymphoproliferative disorder
Multicentric Castleman disease
Unicentric hyaline-vascular Castleman disease

ASJC Scopus subject areas

Surgery
Pathology and Forensic Medicine

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10.1016/j.path.2019.03.003

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title = "Castleman Disease",

abstract = "Castleman disease (CD) is divided clinically into unicentric or multicentric type. Pathologically, CD is divided into hyaline-vascular and plasma cell variants. Unicentric CD is most common, about 75% of these cases are hyaline-vascular variant, and surgical excision is often curative. In contrast, there are a number of types of multicentric CD including HHV8-associated, idiopathic, and a subset of cases that arise in association with POEMS syndrome. Therapy is required for most patients with multicentric CD, but there is no consensus approach currently. As is evidence, the designation Castleman disease encompasses a heterogeneous group of diseases of varied pathogenesis and which require different therapies.",

keywords = "Castleman disease, Human herpes virus type 8, Lymphoproliferative disorder, Multicentric Castleman disease, Unicentric hyaline-vascular Castleman disease",

author = "Wei Wang and Medeiros, {L. Jeffrey}",

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year = "2019",

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AU - Wang, Wei

AU - Medeiros, L. Jeffrey

PY - 2019/9

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N2 - Castleman disease (CD) is divided clinically into unicentric or multicentric type. Pathologically, CD is divided into hyaline-vascular and plasma cell variants. Unicentric CD is most common, about 75% of these cases are hyaline-vascular variant, and surgical excision is often curative. In contrast, there are a number of types of multicentric CD including HHV8-associated, idiopathic, and a subset of cases that arise in association with POEMS syndrome. Therapy is required for most patients with multicentric CD, but there is no consensus approach currently. As is evidence, the designation Castleman disease encompasses a heterogeneous group of diseases of varied pathogenesis and which require different therapies.

AB - Castleman disease (CD) is divided clinically into unicentric or multicentric type. Pathologically, CD is divided into hyaline-vascular and plasma cell variants. Unicentric CD is most common, about 75% of these cases are hyaline-vascular variant, and surgical excision is often curative. In contrast, there are a number of types of multicentric CD including HHV8-associated, idiopathic, and a subset of cases that arise in association with POEMS syndrome. Therapy is required for most patients with multicentric CD, but there is no consensus approach currently. As is evidence, the designation Castleman disease encompasses a heterogeneous group of diseases of varied pathogenesis and which require different therapies.

KW - Castleman disease

KW - Human herpes virus type 8

KW - Lymphoproliferative disorder

KW - Multicentric Castleman disease

KW - Unicentric hyaline-vascular Castleman disease

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Castleman Disease

Abstract

Keywords

ASJC Scopus subject areas

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