TY - JOUR
T1 - CCR6 regulates the migration of inflammatory and regulatory T cells
AU - Yamazaki, Tomohide
AU - Yang, Xuexian O.
AU - Chung, Yeonseok
AU - Fukunaga, Atsushi
AU - Nurieva, Roza
AU - Pappu, Bhanu
AU - Martin-Orozco, Natalia
AU - Kang, Hong Soon
AU - Ma, Li
AU - Panopoulos, Athanasia D.
AU - Craig, Suzanne
AU - Watowich, Stephanie S.
AU - Jetten, Anton M.
AU - Tian, Qiang
AU - Dong, Chen
PY - 2008/12/15
Y1 - 2008/12/15
N2 - Th17 and regulatory T (Treg) cells play opposite roles in autoimmune diseases. However, the mechanisms underlying their proper migration to inflammatory tissues are unclear. In this study, we report that these two T cell subsets both express CCR6. CCR6 expression in Th17 cells is regulated by TGF-β and requires two nuclear receptors, RORα and RORγ. Th17 cells also express the CCR6 ligand CCL20, which is induced synergistically by TGF-β and IL-6, which requires STAT3, RORγ and IL-21. Th17 cells, by producing CCL20, promote migration of Th17 and Treg cells in vitro in a CCR6-dependent manner. Lack of CCR6 in Th17 cells reduces the severity of experimental autoimmune encephalomyelitis and Th17 and Treg recruitment into inflammatory tissues. Similarly, CCR6 on Treg cells is also important for their recruitment into inflammatory tissues. Our data indicate an important role of CCR6 in Treg and Th17 cell migration.
AB - Th17 and regulatory T (Treg) cells play opposite roles in autoimmune diseases. However, the mechanisms underlying their proper migration to inflammatory tissues are unclear. In this study, we report that these two T cell subsets both express CCR6. CCR6 expression in Th17 cells is regulated by TGF-β and requires two nuclear receptors, RORα and RORγ. Th17 cells also express the CCR6 ligand CCL20, which is induced synergistically by TGF-β and IL-6, which requires STAT3, RORγ and IL-21. Th17 cells, by producing CCL20, promote migration of Th17 and Treg cells in vitro in a CCR6-dependent manner. Lack of CCR6 in Th17 cells reduces the severity of experimental autoimmune encephalomyelitis and Th17 and Treg recruitment into inflammatory tissues. Similarly, CCR6 on Treg cells is also important for their recruitment into inflammatory tissues. Our data indicate an important role of CCR6 in Treg and Th17 cell migration.
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U2 - 10.4049/jimmunol.181.12.8391
DO - 10.4049/jimmunol.181.12.8391
M3 - Article
C2 - 19050256
AN - SCOPUS:58849124250
SN - 0022-1767
VL - 181
SP - 8391
EP - 8401
JO - Journal of Immunology
JF - Journal of Immunology
IS - 12
ER -