Abstract
Cutaneous T-cell lymphomas (CTCLs) are subdivided by lesion morphology, behavior, and surface receptors. Mycosis fungoides (MF) and Sézary syndrome (SS) are derived from CD4+ effector or central memory T-cells respectively. MF presents clinically as patches, plaques, or tumors, and SS presents with erythroderma. After MF/SS, the next most common CTCLs are CD30+ lymphoproliferative disorders: self-regressing lymphomatoid papulosis (LyP) or tumors of anaplastic large-cell lymphoma (ALCL), which express high levels of tumor necrosis factor death receptor member 8, also called CD30. Although MF is not considered to be a CD30+ lymphoproliferative disorder, MF may co-exist with LyP lesions, and MF may express CD30, especially in the setting of large-cell transformation. The development of targeted therapy for CD30+ CTCLs will help in understanding the importance of the CD30 death receptor in pathogenesis and will improve treatment options.
Original language | English (US) |
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Pages (from-to) | 245-250 |
Number of pages | 6 |
Journal | Current hematologic malignancy reports |
Volume | 6 |
Issue number | 4 |
DOIs | |
State | Published - Dec 2011 |
Keywords
- ALCL
- Anaplastic large T-cell lymphoma
- Anaplastic lymphoma kinase
- CD30
- Cutaneous T-cell lymphoma
- Hodgkin's lymphoma
- Interferon regulatory factor 4
- Ki-1
- Large-cell transformation
- LyP
- Lymphoma
- Lymphomatoid papulosis
- Mycosis fungoides
- Tumor necrosis factor member 8
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research