CD94 expression patterns in reactive and neoplastic T-cell and NK-cell proliferations

Hong Fang, Wei Wang, Tapan M. Kadia, Siba El Hussein, Sa A. Wang, Joseph D. Khoury

Research output: Contribution to journalArticlepeer-review

Abstract

Lymphomas and leukemias of T-cell and NK-cell lineages are highly heterogeneous disorders and lack effective therapeutic strategies. Targeted therapies including anti-CD94 agents are currently under clinical investigation, but studies of CD94 expression on mature T/NK-cell neoplasms are limited. In this study, we investigated the landscape of CD94 protein expression in 15 patients with reactive T/NK-cell proliferations and 124 patients with various T/NK cell neoplasms. CD94 expression was detected at a high level in reactive NK-cells, with a lower level of expression in a subset of reactive CD8 + T-cells; reactive CD4 + T-cells were negative for CD94 expression. All NK-cell neoplasms surveyed had high-level CD94 expression, which was significantly higher than that in T cell neoplasms (p = 0.0174). In neoplastic T-cell proliferations, CD94 expression was positive in all 10 hepatosplenic T-cell lymphoma cases tested, with a high mean fluorescence intensity. Fifty-six percent of T-cell large granular lymphocytic leukemia cases were positive for CD94 expression in a subset of neoplastic cells. All T-cell prolymphocytic leukemia and 97 % of peripheral T-cell lymphoma cases showed no CD94 expression. Our findings demonstrate a broad range of CD94 expression among T/NK-cell neoplasms, in some at levels that suggest therapeutic vulnerability to CD94-targeted therapies.

Original languageEnglish (US)
Article number106614
JournalLeukemia Research
Volume108
DOIs
StatePublished - Sep 2021

Keywords

  • CD94
  • Flow cytometry
  • NK-cell neoplasm
  • Reactive proliferation
  • T-cell neoplasm

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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