Abstract
Soft tissue sarcomas are rare neoplasms, with approximately 9000 new cases in the USA every year. Unfortunately, during the past two decades, there has been little progress in the treatment of metastatic soft tissue sarcomas beyond the standard approaches of surgery, chemotherapy and radiation. Immunotherapy is a modality complementary to conventional therapy. It is appealing because functional antitumor activity could affect both local-regional and systemic disease, and act over a prolonged period of time. In this report, we review immunotherapeutic investigative strategies that are being developed, including several tumor vaccine, antigen vaccine and dendritic cell vaccine strategies.
Original language | English (US) |
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Pages (from-to) | 283-290 |
Number of pages | 8 |
Journal | Immunotherapy |
Volume | 4 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2012 |
Externally published | Yes |
Keywords
- cytotoxic T lymphocyte
- dendritic cell
- immune-specific response
- immunotherapy
- intratumoral
- neoadjuvant
- radiation therapy
- soft tissue sarcoma
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology