Central interleukin-1 receptors as mediators of sickness

Keith W. Kelley, Kevin Hutchison, Richard French, Rose Marie Bluthé, Patricia Parnet, Rodney W. Johnson, Robert Dantzer

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

These data establish that cytokines, such as IL-1, can act on specific receptors within the brain to induce many symptoms of sickness. A number of inflammatory stimuli in the periphery can activate both the transcription and translation of IL-1 within the central nervous system. It will now be important to determine if similar central IL-1 pathways are activated during SLE and whether these central inflammatory cytokines are involved in the neurologic complications that often accompany this disease.

Original languageEnglish (US)
Pages (from-to)234-246
Number of pages13
JournalAnnals of the New York Academy of Sciences
Volume823
DOIs
StatePublished - Jan 1 1997

Fingerprint

Interleukin-1 Receptors
Interleukin-1
Cytokines
Neurology
Transcription
Nervous System
Brain
Central Nervous System
Sickness
Pathway
Stimulus
Mediator
Complications

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Kelley, K. W., Hutchison, K., French, R., Bluthé, R. M., Parnet, P., Johnson, R. W., & Dantzer, R. (1997). Central interleukin-1 receptors as mediators of sickness. Annals of the New York Academy of Sciences, 823, 234-246. https://doi.org/10.1111/j.1749-6632.1997.tb48395.x

Central interleukin-1 receptors as mediators of sickness. / Kelley, Keith W.; Hutchison, Kevin; French, Richard; Bluthé, Rose Marie; Parnet, Patricia; Johnson, Rodney W.; Dantzer, Robert.

In: Annals of the New York Academy of Sciences, Vol. 823, 01.01.1997, p. 234-246.

Research output: Contribution to journalArticle

Kelley, KW, Hutchison, K, French, R, Bluthé, RM, Parnet, P, Johnson, RW & Dantzer, R 1997, 'Central interleukin-1 receptors as mediators of sickness', Annals of the New York Academy of Sciences, vol. 823, pp. 234-246. https://doi.org/10.1111/j.1749-6632.1997.tb48395.x
Kelley KW, Hutchison K, French R, Bluthé RM, Parnet P, Johnson RW et al. Central interleukin-1 receptors as mediators of sickness. Annals of the New York Academy of Sciences. 1997 Jan 1;823:234-246. https://doi.org/10.1111/j.1749-6632.1997.tb48395.x
Kelley, Keith W. ; Hutchison, Kevin ; French, Richard ; Bluthé, Rose Marie ; Parnet, Patricia ; Johnson, Rodney W. ; Dantzer, Robert. / Central interleukin-1 receptors as mediators of sickness. In: Annals of the New York Academy of Sciences. 1997 ; Vol. 823. pp. 234-246.
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