Central interleukin-1 receptors as mediators of sickness

Keith W. Kelley; Kevin Hutchison; Richard French; Rose Marie Bluthé; Patricia Parnet; Rodney W. Johnson; Robert Dantzer

doi:10.1111/j.1749-6632.1997.tb48395.x

Central interleukin-1 receptors as mediators of sickness

Keith W. Kelley, Kevin Hutchison, Richard French, Rose Marie Bluthé, Patricia Parnet, Rodney W. Johnson, Robert Dantzer

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

These data establish that cytokines, such as IL-1, can act on specific receptors within the brain to induce many symptoms of sickness. A number of inflammatory stimuli in the periphery can activate both the transcription and translation of IL-1 within the central nervous system. It will now be important to determine if similar central IL-1 pathways are activated during SLE and whether these central inflammatory cytokines are involved in the neurologic complications that often accompany this disease.

Original language	English (US)
Pages (from-to)	234-246
Number of pages	13
Journal	Annals of the New York Academy of Sciences
Volume	823
DOIs	https://doi.org/10.1111/j.1749-6632.1997.tb48395.x
State	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1111/j.1749-6632.1997.tb48395.x

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AU - Kelley, Keith W.

AU - Hutchison, Kevin

AU - French, Richard

AU - Bluthé, Rose Marie

AU - Parnet, Patricia

AU - Johnson, Rodney W.

AU - Dantzer, Robert

PY - 1997

Y1 - 1997

N2 - These data establish that cytokines, such as IL-1, can act on specific receptors within the brain to induce many symptoms of sickness. A number of inflammatory stimuli in the periphery can activate both the transcription and translation of IL-1 within the central nervous system. It will now be important to determine if similar central IL-1 pathways are activated during SLE and whether these central inflammatory cytokines are involved in the neurologic complications that often accompany this disease.

AB - These data establish that cytokines, such as IL-1, can act on specific receptors within the brain to induce many symptoms of sickness. A number of inflammatory stimuli in the periphery can activate both the transcription and translation of IL-1 within the central nervous system. It will now be important to determine if similar central IL-1 pathways are activated during SLE and whether these central inflammatory cytokines are involved in the neurologic complications that often accompany this disease.

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JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Central interleukin-1 receptors as mediators of sickness

Abstract

ASJC Scopus subject areas

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