TY - JOUR
T1 - Change in postsurgical cavity size within the first 30 days correlates with extent of surrounding edema
T2 - Consequences for postoperative radiosurgery
AU - Ahmed, Salmaan
AU - Hamilton, Jackson
AU - Colen, Rivka
AU - Schellingerhout, Dawid
AU - Vu, Thinh
AU - Rao, Ganesh
AU - McAleer, Mary Frances
AU - Mahajan, Anita
PY - 2014
Y1 - 2014
N2 - OBJECTIVE: Resection cavity diameter of less than 40 mm is required to be eligible for stereotactic radiosurgery (SRS), after gross total resection of brain metastasis at our institution. Our study evaluates the correlation between vasogenic edema and change in cavity size for 30 days. METHODS: Cavity size was measured on the postoperative and follow-up magnetic resonance imaging. Vasogenic edema was quantified as the largest axial measurement of T2 hyperintensity surrounding the resection cavity (postoperative magnetic resonance imaging). RESULTS: Thirty-nine resection cavities (37 patients) were reviewed. There was a statistically significant (Pearson coefficient =-0.35; P = 0.02) negative correlation between edema and change in cavity size. An arbitrary cutoff value of a 15-mm edema yielded a sensitivity of 96% and a specificity of 65% (P < 0.001) to predict 10% decrease in cavity size. CONCLUSIONS: In patients with cavity size close to the size cutoff for SRS, rescanning closer to the date of SRS should be considered, especially if there is significant edema surrounding the cavity.
AB - OBJECTIVE: Resection cavity diameter of less than 40 mm is required to be eligible for stereotactic radiosurgery (SRS), after gross total resection of brain metastasis at our institution. Our study evaluates the correlation between vasogenic edema and change in cavity size for 30 days. METHODS: Cavity size was measured on the postoperative and follow-up magnetic resonance imaging. Vasogenic edema was quantified as the largest axial measurement of T2 hyperintensity surrounding the resection cavity (postoperative magnetic resonance imaging). RESULTS: Thirty-nine resection cavities (37 patients) were reviewed. There was a statistically significant (Pearson coefficient =-0.35; P = 0.02) negative correlation between edema and change in cavity size. An arbitrary cutoff value of a 15-mm edema yielded a sensitivity of 96% and a specificity of 65% (P < 0.001) to predict 10% decrease in cavity size. CONCLUSIONS: In patients with cavity size close to the size cutoff for SRS, rescanning closer to the date of SRS should be considered, especially if there is significant edema surrounding the cavity.
KW - brain metastasis
KW - edema
KW - gross total resection
KW - stereotactic radiosurgery
UR - http://www.scopus.com/inward/record.url?scp=84901497875&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901497875&partnerID=8YFLogxK
U2 - 10.1097/RCT.0000000000000058
DO - 10.1097/RCT.0000000000000058
M3 - Article
C2 - 24681852
AN - SCOPUS:84901497875
SN - 0363-8715
VL - 38
SP - 457
EP - 460
JO - Journal of computer assisted tomography
JF - Journal of computer assisted tomography
IS - 3
ER -