Changes in pancreatic fat content following diet-induced weight loss

Yixin Jiang, Manuela Spurny, Ruth Schübel, Tobias Nonnenmacher, Christopher L. Schlett, Oyunbileg Von Stackelberg, Cornelia M. Ulrich, Rudolf Kaaks, Hans Ulrich Kauczor, Tilman Kühn, Johanna Nattenmüller

Research output: Contribution to journalArticle

Abstract

Background: Obesity can lead to ectopic pancreatic fat accumulation and increase the risk for type 2 diabetes. Smaller intervention trials have shown a decrease in pancreatic fat content (PFC) with weight loss, and we intended to investigate the effects of weight loss on PFC in a larger trial. Methods: Data from the HELENA-Trial, a randomized controlled trial (RCT) among 137 non-diabetic obese adults were used. The study cohort was classified into 4 quartiles based on weight change between baseline and 12 weeks post-intervention. Changes in PFC (baseline, 12 weeks and 50 weeks post-intervention) upon weight loss were analyzed by linear mixed models. Spearman’s coefficients were used to obtain correlations between anthropometric parameters, blood biochemical markers, and PFC. Results: At baseline, PFC only showed a significant correlation with visceral adipose tissue (VAT) (r = 0.41). Relative changes in PFC were significantly (p = 0.01) greater in Q4 (−30.8 ± 5.7%) than in Q1 (1.3 ± 6.7%). These differences remained similar after one year. However, when adjusting the statistical analyses for changes in VAT, the differences in PFC between Q1 and Q4 were no longer statistically significant. Conclusion: Weight loss is associated with a decrease in PFC. However, the reduction of PFC is not independent from reductions in VAT. Unlike VAT, PFC was not associated with metabolic biomarkers.

Original languageEnglish (US)
Article number912
JournalNutrients
Volume11
Issue number4
DOIs
StatePublished - Apr 2019

Fingerprint

Reducing Diet
weight loss
Fats
lipid content
diet
Intra-Abdominal Fat
adipose tissue
Weight Loss
biomarkers
Biomarkers
cohort studies
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
obesity
Linear Models
Cohort Studies
Randomized Controlled Trials
Obesity

Keywords

  • Diet-induced weight loss
  • Ectopic fat accumulation
  • Insulin sensitivity
  • Magnetic resonance imaging
  • Pancreatic fat content

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Jiang, Y., Spurny, M., Schübel, R., Nonnenmacher, T., Schlett, C. L., Von Stackelberg, O., ... Nattenmüller, J. (2019). Changes in pancreatic fat content following diet-induced weight loss. Nutrients, 11(4), [912]. https://doi.org/10.3390/nu11040912

Changes in pancreatic fat content following diet-induced weight loss. / Jiang, Yixin; Spurny, Manuela; Schübel, Ruth; Nonnenmacher, Tobias; Schlett, Christopher L.; Von Stackelberg, Oyunbileg; Ulrich, Cornelia M.; Kaaks, Rudolf; Kauczor, Hans Ulrich; Kühn, Tilman; Nattenmüller, Johanna.

In: Nutrients, Vol. 11, No. 4, 912, 04.2019.

Research output: Contribution to journalArticle

Jiang, Y, Spurny, M, Schübel, R, Nonnenmacher, T, Schlett, CL, Von Stackelberg, O, Ulrich, CM, Kaaks, R, Kauczor, HU, Kühn, T & Nattenmüller, J 2019, 'Changes in pancreatic fat content following diet-induced weight loss', Nutrients, vol. 11, no. 4, 912. https://doi.org/10.3390/nu11040912
Jiang Y, Spurny M, Schübel R, Nonnenmacher T, Schlett CL, Von Stackelberg O et al. Changes in pancreatic fat content following diet-induced weight loss. Nutrients. 2019 Apr;11(4). 912. https://doi.org/10.3390/nu11040912
Jiang, Yixin ; Spurny, Manuela ; Schübel, Ruth ; Nonnenmacher, Tobias ; Schlett, Christopher L. ; Von Stackelberg, Oyunbileg ; Ulrich, Cornelia M. ; Kaaks, Rudolf ; Kauczor, Hans Ulrich ; Kühn, Tilman ; Nattenmüller, Johanna. / Changes in pancreatic fat content following diet-induced weight loss. In: Nutrients. 2019 ; Vol. 11, No. 4.
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