Changing concepts in the management of hereditary and sporadic medullary thyroid carcinoma

A. Grauer, F. Raue, R. F. Gagel

Research output: Contribution to journalReview article

49 Citations (Scopus)

Abstract

Recent linkage of the gene for multiple endocrine neoplasia type 2A and 2B to the centrometric region of chromosome 10 has provided new insight into the causes of medullary thyroid carcinoma and has provided tools to diagnose gene carriers status for this syndrome with greater than 90% certainty. This review focuses on how these advances influence the clinical management of both sporadic and hereditary medullary thyroid carcinoma and discusses how tests based on the genetic linkage studies will aid in the early diagnosis and treatment of this syndrome. In addition, the authors have focused on several controversial management questions regarding the type and extent of surgery for this thyroid tumor, the management of the patient with metastatic disease, and the approach to management of other manifestations of multiple endocrine neoplasia types 2A and 2B. This review attempts to provide a balanced overview of these complex issues.

Original languageEnglish (US)
Pages (from-to)613-635
Number of pages23
JournalEndocrinology and Metabolism Clinics of North America
Volume19
Issue number3
StatePublished - Sep 28 1990

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Multiple Endocrine Neoplasia Type 2b
Multiple Endocrine Neoplasia Type 2a
Chromosomes, Human, Pair 10
Genetic Linkage
Genes
Early Diagnosis
Thyroid Gland
Chromosomes
Surgery
Tumors
Neoplasms
Medullary Thyroid cancer
Therapeutics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Changing concepts in the management of hereditary and sporadic medullary thyroid carcinoma. / Grauer, A.; Raue, F.; Gagel, R. F.

In: Endocrinology and Metabolism Clinics of North America, Vol. 19, No. 3, 28.09.1990, p. 613-635.

Research output: Contribution to journalReview article

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