TY - JOUR
T1 - Characteristics of secretory breast carcinoma with extensive in situ carcinoma components
T2 - Clinical and histopathologic analysis
AU - Liang, Tom Z.
AU - Ding, Qingqing
AU - Middleton, Lavinia P.
AU - Wu, Yun
AU - Sahin, Aysegul A
N1 - Publisher Copyright:
© 2024
PY - 2024/9
Y1 - 2024/9
N2 - Secretory breast carcinoma is a rare form of breast cancer characterized by low-grade histology, presence of intracellular eosinophilic secretions, and ETV6-NTRK3 fusion. Although several studies have explored the histopathologic features of secretory carcinoma, limited attention has been given to the in situ component. We report 5 cases of secretory breast carcinoma with an extensive intraductal component and describe morphologic and biologic characteristics of the in-situ component of secretory breast carcinoma, along with a detailed review of the literature, and discuss potential diagnostic pitfalls in erroneously identifying the in situ lesion as florid hyperplasia.
AB - Secretory breast carcinoma is a rare form of breast cancer characterized by low-grade histology, presence of intracellular eosinophilic secretions, and ETV6-NTRK3 fusion. Although several studies have explored the histopathologic features of secretory carcinoma, limited attention has been given to the in situ component. We report 5 cases of secretory breast carcinoma with an extensive intraductal component and describe morphologic and biologic characteristics of the in-situ component of secretory breast carcinoma, along with a detailed review of the literature, and discuss potential diagnostic pitfalls in erroneously identifying the in situ lesion as florid hyperplasia.
KW - Biomarkers
KW - Clinicopathologic features
KW - Ductal carcinoma in situ of breast
KW - Intraductal proliferations with secretory patterns
KW - Secretory carcinoma of breast
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U2 - 10.1016/j.hpr.2024.300755
DO - 10.1016/j.hpr.2024.300755
M3 - Article
AN - SCOPUS:85200140788
SN - 2772-736X
VL - 37
JO - Human Pathology Reports
JF - Human Pathology Reports
M1 - 300755
ER -