TY - JOUR
T1 - Characterization of continuous bed motion effects on patient breathing and respiratory motion correction in PET/CT imaging
AU - Meier, Joseph G.
AU - Erasmus, Jeremy J.
AU - Gladish, Gregory W.
AU - Peterson, Christine B.
AU - Diab, Radwan H.
AU - Mawlawi, Osama R.
N1 - Funding Information:
This work was supported in part by a research grant from SIEMENS Healthineers. We thank Drs. James Hamill and Judson Jones from Siemens for their technical support in describing the recorded patient respiratory waveforms. In addition, we thank the Department of Scientific Publications for their contribution in the editing of our manuscript for publication. Finally, Christine Peterson is partially supported by NIH/NCI CCSG grant P30CA016672 (Biostatistics shared resource).
Funding Information:
This work was supported in part by a research grant from SIEMENS Healthineers.
Funding Information:
This work was supported in part by a research grant from SIEMENS Healthineers. We thank Drs. James Hamill and Judson Jones from Siemens for their technical support in describing the recorded patient respiratory waveforms. In addition, we thank the Department of Scientific Publications for their contribution in the editing of our manuscript for publication. Finally, Christine Peterson is partially supported by NIH/NCI CCSG grant P30CA016672 (Biostatistics shared resource).
Publisher Copyright:
© 2019 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Continuous bed motion (CBM) was recently introduced as an alternative to step-and-shoot (SS) mode for PET/CT data acquisition. In CBM, the patient is continuously advanced into the scanner at a preset speed, whereas in SS, the patient is imaged in overlapping bed positions. Previous investigations have shown that patients preferred CBM over SS for PET data acquisition. In this study, we investigated the effect of CBM versus SS on patient breathing and respiratory motion correction. One hundred patients referred for PET/CT were scanned using a Siemens mCT scanner. Patient respiratory waveforms were recorded using an Anzai system and analyzed using four methods: Methods 1 and 2 measured the coefficient of variation (COV) of the respiratory cycle duration (RCD) and amplitude (RCA). Method 3 measured the respiratory frequency signal prominence (RSP) and method 4 measured the width of the HDChest optimal gate (OG) window when using a 35% duty cycle. Waveform analysis was performed over the abdominothoracic region which exhibited the greatest respiratory motion and the results were compared between CBM and SS. Respiratory motion correction was assessed by comparing the ratios of SUVmax, SUVpeak, and CNR of focal FDG uptake, as well as Radiologists’ visual assessment of corresponding image quality of motion corrected and uncorrected images for both acquisition modes. The respiratory waveforms analysis showed that the RCD and RCA COV were 3.7% and 33.3% lower for CBM compared to SS, respectively, while the RSP and OG were 30.5% and 2.0% higher, respectively. Image analysis on the other hand showed that SUVmax, SUVpeak, and CNR were 8.5%, 4.5%, and 3.4% higher for SS compared to CBM, respectively, while the Radiologists’ visual comparison showed similar image quality between acquisition modes. However, none of the results showed statistically significant differences between SS and CBM, suggesting that motion correction is not impacted by acquisition mode.
AB - Continuous bed motion (CBM) was recently introduced as an alternative to step-and-shoot (SS) mode for PET/CT data acquisition. In CBM, the patient is continuously advanced into the scanner at a preset speed, whereas in SS, the patient is imaged in overlapping bed positions. Previous investigations have shown that patients preferred CBM over SS for PET data acquisition. In this study, we investigated the effect of CBM versus SS on patient breathing and respiratory motion correction. One hundred patients referred for PET/CT were scanned using a Siemens mCT scanner. Patient respiratory waveforms were recorded using an Anzai system and analyzed using four methods: Methods 1 and 2 measured the coefficient of variation (COV) of the respiratory cycle duration (RCD) and amplitude (RCA). Method 3 measured the respiratory frequency signal prominence (RSP) and method 4 measured the width of the HDChest optimal gate (OG) window when using a 35% duty cycle. Waveform analysis was performed over the abdominothoracic region which exhibited the greatest respiratory motion and the results were compared between CBM and SS. Respiratory motion correction was assessed by comparing the ratios of SUVmax, SUVpeak, and CNR of focal FDG uptake, as well as Radiologists’ visual assessment of corresponding image quality of motion corrected and uncorrected images for both acquisition modes. The respiratory waveforms analysis showed that the RCD and RCA COV were 3.7% and 33.3% lower for CBM compared to SS, respectively, while the RSP and OG were 30.5% and 2.0% higher, respectively. Image analysis on the other hand showed that SUVmax, SUVpeak, and CNR were 8.5%, 4.5%, and 3.4% higher for SS compared to CBM, respectively, while the Radiologists’ visual comparison showed similar image quality between acquisition modes. However, none of the results showed statistically significant differences between SS and CBM, suggesting that motion correction is not impacted by acquisition mode.
KW - PET/CT
KW - SUV quantification
KW - continuous bed motion
KW - lesion detectability
KW - patient breathing repeatability
KW - respiratory motion correction
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U2 - 10.1002/acm2.12785
DO - 10.1002/acm2.12785
M3 - Article
C2 - 31816183
AN - SCOPUS:85076532271
SN - 1526-9914
VL - 21
SP - 158
EP - 165
JO - Journal of applied clinical medical physics
JF - Journal of applied clinical medical physics
IS - 1
ER -