Characterization of in vitro and in vivo bioactivity of a ferulic acid-2-Hydroxypropyl-β-cyclodextrin inclusion complex

Chin Mu Hsu, Song Cu Yu, Fuu-Jen Tsai, Yuhsin Tsai

Research output: Contribution to journalArticle

Abstract

Ferulic acid (FA) belongs to the family of phenolic acids and exhibits a wide variety of biological activities. However, the bioavailability of FA is not optimal, owing to its limited aqueous solubility. Several methods have been developed to increase FA bioavailability and enhance its cytoprotective effects. Complexing FA with cyclodextrins (CDs) may provide an alternative method to approach these goals. In this study, we prepared an FA-2-hydroxypropyl-β-CD (FA-HP-β-CD) complex, at a 1:1 M ratio of FA to HP-β-CD, which was characterized by 1 H NMR, two-dimensional rotating frame spectroscopy and differential scanning calorimetry. Aqueous solubility of FA was improved after complexing with HP-β-CD. Furthermore, in vitro and in vivo experimental results indicated that the FA-HP-β-CD complex had greater bioactivity than FA alone. Therefore, we can conclude that the limitations of FA usage due to low aqueous solubility and bioavailability can be overcome by creating an HP-β-CD inclusion complex with the hydrophobic FA.

Original languageEnglish (US)
Pages (from-to)68-74
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
Volume180
DOIs
StatePublished - Aug 1 2019

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ferulic acid
Cyclodextrins
Bioactivity
inclusions
acids
Acids
bioavailability
Solubility
Biological Availability
solubility
In Vitro Techniques

Keywords

  • 2-Hydroxypropyl-β-cyclodextrin
  • Bioactivity
  • Ferulic acid
  • In vitro
  • In vivo

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

Characterization of in vitro and in vivo bioactivity of a ferulic acid-2-Hydroxypropyl-β-cyclodextrin inclusion complex. / Hsu, Chin Mu; Yu, Song Cu; Tsai, Fuu-Jen; Tsai, Yuhsin.

In: Colloids and Surfaces B: Biointerfaces, Vol. 180, 01.08.2019, p. 68-74.

Research output: Contribution to journalArticle

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AU - Tsai, Yuhsin

PY - 2019/8/1

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