Chemical constituents and biological studies of the leaves of grevillea robusta

Ta Hsien Chuang, Hsiu Hui Chan, Tian Shung Wu, Chien Fu Li

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Three new compounds: Graviquinone (1), cis-3-hydroxy-5- pentadecylcyclohexanone (2), and methyl 5-ethoxy-2-hydroxycinnamate (3), and thirty-eight known compounds were isolated and identified from the leaves of Grevillea robusta. The structures of these compounds were determined by spectroscopic and chemical transformation methods. Graviquinone (1) showed the strongest cytotoxicity against MCF-7, NCI-H460, and SF-268 cell lines. Methyl 2,5-dihydroxycinnamate (4), graviphane (13), and dehydrograviphane (14) exhibited very potent DPPH scavenging activity compared with α-tocopherol. Methyl 2,5-dihydroxycinnamate (4) and bis-norstriatol (17) demonstrated strong inhibition of L-DOPA oxidation by mushroom tyrosinase compared with kojic acid.

Original languageEnglish (US)
Pages (from-to)9331-9339
Number of pages9
JournalMolecules
Volume16
Issue number11
DOIs
StatePublished - Nov 1 2011

Fingerprint

Proteaceae
tocopherol
scavenging
cultured cells
leaves
oxidation
acids
Tocopherols
Monophenol Monooxygenase
Agaricales
Scavenging
Cytotoxicity
Cells
Cell Line
Oxidation
methyl 2,5-dihydroxycinnamate

Keywords

  • Cytotoxicity
  • DPPH
  • Grevillea robusta
  • Proteaceae
  • Tyrosinase inhibition activity

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Chemical constituents and biological studies of the leaves of grevillea robusta. / Chuang, Ta Hsien; Chan, Hsiu Hui; Wu, Tian Shung; Li, Chien Fu.

In: Molecules, Vol. 16, No. 11, 01.11.2011, p. 9331-9339.

Research output: Contribution to journalArticle

Chuang, Ta Hsien ; Chan, Hsiu Hui ; Wu, Tian Shung ; Li, Chien Fu. / Chemical constituents and biological studies of the leaves of grevillea robusta. In: Molecules. 2011 ; Vol. 16, No. 11. pp. 9331-9339.
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