Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity

Che Wei Lin, Tsong Long Hwang, Fu An Chen, Chia Hsin Huang, Hsin Yi Hung, Tian Shung Wu

    Research output: Contribution to journalArticle

    14 Scopus citations

    Abstract

    Nine new phenanthrenes (1-9) and a new benzyl glycoside (10) together with 45 known compounds were isolated from the rhizomes of Bletilla formosana. The structures of 1-10 were elucidated primarily on the basis of their 1D and 2D NMR spectroscopic data. Most of the isolated compounds were evaluated for their anti-inflammatory activities. The results showed that IC50 values for the inhibition of superoxide anion generation and elastase release ranged from 0.2 to 6.5 μM and 0.3 to 5.7 μM, respectively. Structure-activity relationships of the isolated compounds were also investigated. The inhibitory potencies were determined as phenanthrenes > bibenzyls > biphenanthrenes.

    Original languageEnglish (US)
    Pages (from-to)1911-1921
    Number of pages11
    JournalJournal of Natural Products
    Volume79
    Issue number8
    DOIs
    StatePublished - Aug 26 2016

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Molecular Medicine
    • Pharmacology
    • Pharmaceutical Science
    • Drug Discovery
    • Complementary and alternative medicine
    • Organic Chemistry

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