Chemokine decoy receptor D6 plays a negative role in human breast cancer

Feng Ying Wu, Zhou Luo Ou, Lan Yun Feng, Jian Min Luo, Lei Ping Wang, Zhen Zhou Shen, Zhi Min Shao

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Chemokine binding protein D6 is a promiscuous decoy receptor that can inhibit inflammation in vivo; however, the role it plays in cancer is not well known yet. In this study, we showed for the first time that human breast cancer differentially expressed D6 and the expression could be regulated by some cytokines. More importantly, overexpression of D6 in human breast cancer cells inhibits proliferation and invasion in vitro and tumorigenesis and lung metastasis in vivo. This inhibition is associated with decreased chemokines (e.g., CCL2 and CCL5), vessel density, and tumor-associated macrophage infiltration. Furthermore, D6 expression is inversely correlated to lymph node metastasis as well as clinical stages, but positively correlated to disease-free survival rate in cancer patients. Therefore, D6 plays a negative role in the growth and metastasis of breast cancer.

Original languageEnglish (US)
Pages (from-to)1276-1288
Number of pages13
JournalMolecular Cancer Research
Volume6
Issue number8
DOIs
StatePublished - Aug 1 2008

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Breast Neoplasms
Neoplasm Metastasis
Chemokine CCL5
Neoplasms
Chemokine CCL2
Chemokines
Disease-Free Survival
Carrier Proteins
Carcinogenesis
Survival Rate
Lymph Nodes
Macrophages
Cell Proliferation
Cytokines
Inflammation
Lung
Growth
chemokine receptor D6
In Vitro Techniques

ASJC Scopus subject areas

  • Molecular Biology
  • Oncology
  • Cancer Research

Cite this

Chemokine decoy receptor D6 plays a negative role in human breast cancer. / Wu, Feng Ying; Ou, Zhou Luo; Feng, Lan Yun; Luo, Jian Min; Wang, Lei Ping; Shen, Zhen Zhou; Shao, Zhi Min.

In: Molecular Cancer Research, Vol. 6, No. 8, 01.08.2008, p. 1276-1288.

Research output: Contribution to journalArticle

Wu, Feng Ying ; Ou, Zhou Luo ; Feng, Lan Yun ; Luo, Jian Min ; Wang, Lei Ping ; Shen, Zhen Zhou ; Shao, Zhi Min. / Chemokine decoy receptor D6 plays a negative role in human breast cancer. In: Molecular Cancer Research. 2008 ; Vol. 6, No. 8. pp. 1276-1288.
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AU - Shao, Zhi Min

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