TY - JOUR
T1 - Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes
AU - Jyonouchi, Harumi
AU - Geng, Lee
AU - Streck, Deanna L.
AU - Toruner, Gokce A.
N1 - Funding Information:
This study was supported by generous grants from Jonty Foundation, St. Paul, MN , and Autism Research Institute, San Diego, CA . The authors are thankful for Dr. L. Huguienin for her critical review of this manuscript.
PY - 2011/9/15
Y1 - 2011/9/15
N2 - Innate/adaptive immune responses and transcript profiles of peripheral blood monocytes were studied in ASD children who exhibit fluctuating behavioral symptoms following infection and other immune insults (ASD/Inf, N = 30). The ASD/Inf children with persistent gastrointestinal symptoms (ASD/Inf + GI, N = 19), revealed less production of proinflammatory and counter-regulatory cytokines with stimuli of innate immunity and marked changes in transcript profiles of monocytes as compared to ASD/no-Inf (N = 28) and normal (N = 26) controls. This included a 4-5 fold up-regulation of chemokines (CCL2 and CCL7), consistent with the production of more CCL2 by ASD/Inf + GI cells. These results indicate dysregulated innate immune defense in the ASD/Inf + GI children, rendering them more vulnerable to common microbial infection/dysbiosis and possibly subsequent behavioral changes.
AB - Innate/adaptive immune responses and transcript profiles of peripheral blood monocytes were studied in ASD children who exhibit fluctuating behavioral symptoms following infection and other immune insults (ASD/Inf, N = 30). The ASD/Inf children with persistent gastrointestinal symptoms (ASD/Inf + GI, N = 19), revealed less production of proinflammatory and counter-regulatory cytokines with stimuli of innate immunity and marked changes in transcript profiles of monocytes as compared to ASD/no-Inf (N = 28) and normal (N = 26) controls. This included a 4-5 fold up-regulation of chemokines (CCL2 and CCL7), consistent with the production of more CCL2 by ASD/Inf + GI cells. These results indicate dysregulated innate immune defense in the ASD/Inf + GI children, rendering them more vulnerable to common microbial infection/dysbiosis and possibly subsequent behavioral changes.
KW - Autism spectrum disorders (ASD)
KW - CCL2
KW - Cytokines
KW - Peripheral blood (PB) monocytes
KW - TLRs
KW - Transcript profiling
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U2 - 10.1016/j.jneuroim.2011.07.001
DO - 10.1016/j.jneuroim.2011.07.001
M3 - Article
C2 - 21803429
AN - SCOPUS:80052864423
SN - 0165-5728
VL - 238
SP - 73
EP - 80
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -