TY - JOUR
T1 - Chimeric antibody receptors (CARs)
T2 - driving T-cell specificity to enhance anti-tumor immunity.
AU - Kebriaei, Partow
AU - Kelly, Susan S.
AU - Manuri, Pallavi
AU - Jena, Bipulendu
AU - Jackson, Rineka
AU - Shpall, Elizabeth
AU - Champlin, Richard
AU - Cooper, Laurence J N
PY - 2012
Y1 - 2012
N2 - Adoptive transfer of antigen-specific T cells is a compelling tool to treat cancer. To overcome issues of immune tolerance which limits the endogenous adaptive immune response to tumor-associated antigens, robust systems for the genetic modification and characterization of T cells expressing chimeric antigen receptors (CARs) to redirect specificity have been produced. Refinements with regards to persistence and trafficking of the genetically modified T cells are underway to help improve the potency of genetically modified T cells. Clinical trials utilizing this technology demonstrate feasibility, and increasingly, antitumor activity, paving the way for multi-center trials to establish the efficacy of this novel T-cell therapy.
AB - Adoptive transfer of antigen-specific T cells is a compelling tool to treat cancer. To overcome issues of immune tolerance which limits the endogenous adaptive immune response to tumor-associated antigens, robust systems for the genetic modification and characterization of T cells expressing chimeric antigen receptors (CARs) to redirect specificity have been produced. Refinements with regards to persistence and trafficking of the genetically modified T cells are underway to help improve the potency of genetically modified T cells. Clinical trials utilizing this technology demonstrate feasibility, and increasingly, antitumor activity, paving the way for multi-center trials to establish the efficacy of this novel T-cell therapy.
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M3 - Review article
C2 - 22202074
SN - 1945-0516
VL - 4
SP - 520
EP - 531
JO - Frontiers in bioscience (Scholar edition)
JF - Frontiers in bioscience (Scholar edition)
ER -