Abstract
To test the possible role of cholecystokinin (CCK) in the decrease of social exploration induced by intraperitoneal (IP) injection of lipopolysaccharide (LPS, 100 μg/kg), mice were pretreated with IP or intracerebroventricular (ICV) injection of the CCKA receptor antagonist L-364,718 (3 mg/kg and 10 μg/kg, respectively) and the CCKB receptor antagonist L-365,260 (1 mg/kg and 10 μg/kg, respectively). L-364,718 and L-365,260 did not alter LPS-induced decrease in social investigation, whatever the route of administration, suggesting that endogenous cholecystokinin does not mediate the effect of proinflammatory cytokines on social exploration in mice.
Original language | English (US) |
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Pages (from-to) | 385-389 |
Number of pages | 5 |
Journal | Physiology and Behavior |
Volume | 62 |
Issue number | 2 |
DOIs | |
State | Published - Aug 1997 |
Externally published | Yes |
Keywords
- Behavior
- CCK-A receptors
- CCK-B receptors
- Cholecystokinin (CCK)
- Lipopolysaccharide
- Mice
- Sickness
- Social exploration
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Behavioral Neuroscience