Cholecystokinin receptors do not mediate the behavioral effects of lipopolysaccharide in mice

Rose Marie Bluthé, Bruno Michaud, Keith W. Kelley, Robert Dantzer

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

To test the possible role of cholecystokinin (CCK) in the decrease of social exploration induced by intraperitoneal (IP) injection of lipopolysaccharide (LPS, 100 μg/kg), mice were pretreated with IP or intracerebroventricular (ICV) injection of the CCKA receptor antagonist L-364,718 (3 mg/kg and 10 μg/kg, respectively) and the CCKB receptor antagonist L-365,260 (1 mg/kg and 10 μg/kg, respectively). L-364,718 and L-365,260 did not alter LPS-induced decrease in social investigation, whatever the route of administration, suggesting that endogenous cholecystokinin does not mediate the effect of proinflammatory cytokines on social exploration in mice.

Original languageEnglish (US)
Pages (from-to)385-389
Number of pages5
JournalPhysiology and Behavior
Volume62
Issue number2
DOIs
StatePublished - Aug 1997

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Keywords

  • Behavior
  • CCK-A receptors
  • CCK-B receptors
  • Cholecystokinin (CCK)
  • Lipopolysaccharide
  • Mice
  • Sickness
  • Social exploration

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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