TY - JOUR
T1 - Chromatin modifiers and remodellers
T2 - Regulators of cellular differentiation
AU - Chen, Taiping
AU - Dent, Sharon Y.R.
N1 - Funding Information:
Work in T.C.’s laboratory is supported by the Cancer Prevention and Research Institute of Texas (CPRIT). T.C. is a CPRIT Scholar in Cancer Research; S.Y.R.D.’s support includes two grants from the US National Institutes of Health, GM067718 and GM096472.
PY - 2014/2
Y1 - 2014/2
N2 - Cellular differentiation is, by definition, epigenetic. Genome-wide profiling of pluripotent cells and differentiated cells suggests global chromatin remodelling during differentiation, which results in a progressive transition from a fairly open chromatin configuration to a more compact state. Genetic studies in mouse models show major roles for a variety of histone modifiers and chromatin remodellers in key developmental transitions, such as the segregation of embryonic and extra-embryonic lineages in blastocyst stage embryos, the formation of the three germ layers during gastrulation and the differentiation of adult stem cells. Furthermore, rather than merely stabilizing the gene expression changes that are driven by developmental transcription factors, there is emerging evidence that chromatin regulators have multifaceted roles in cell fate decisions.
AB - Cellular differentiation is, by definition, epigenetic. Genome-wide profiling of pluripotent cells and differentiated cells suggests global chromatin remodelling during differentiation, which results in a progressive transition from a fairly open chromatin configuration to a more compact state. Genetic studies in mouse models show major roles for a variety of histone modifiers and chromatin remodellers in key developmental transitions, such as the segregation of embryonic and extra-embryonic lineages in blastocyst stage embryos, the formation of the three germ layers during gastrulation and the differentiation of adult stem cells. Furthermore, rather than merely stabilizing the gene expression changes that are driven by developmental transcription factors, there is emerging evidence that chromatin regulators have multifaceted roles in cell fate decisions.
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U2 - 10.1038/nrg3607
DO - 10.1038/nrg3607
M3 - Review article
C2 - 24366184
AN - SCOPUS:84892814234
SN - 1471-0056
VL - 15
SP - 93
EP - 106
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 2
ER -