TY - JOUR
T1 - Chromatin
T2 - Receiver and quarterback for cellular signals
AU - Johnson, David G.
AU - Dent, Sharon Y.R.
N1 - Funding Information:
We thank Becky Brooks for preparation of the manuscript, Chris Brown for graphics, and Mark Bedford and Boyko Atanassov for suggestions and insightful comments. This research is supported, in part, by grants from the National Institutes of Health (CA079648 to D.G.J. and GM096472 and GM067718 to S.R.D.) and through MD Anderson’s Cancer Center Support Grant (CA016672).
PY - 2013/2/14
Y1 - 2013/2/14
N2 - Signal transduction pathways converge upon sequence-specific DNA binding factors to reprogram gene expression. Transcription factors, in turn, team up with chromatin modifying activities. However, chromatin is not simply an endpoint for signaling pathways. Histone modifications relay signals to other proteins to trigger more immediate responses than can be achieved through altered gene transcription, which might be especially important to time-urgent processes such as the execution of cell-cycle check points, chromosome segregation, or exit from mitosis. In addition, histone-modifying enzymes often have multiple nonhistone substrates, and coordination of activity toward different targets might direct signals both to and from chromatin.
AB - Signal transduction pathways converge upon sequence-specific DNA binding factors to reprogram gene expression. Transcription factors, in turn, team up with chromatin modifying activities. However, chromatin is not simply an endpoint for signaling pathways. Histone modifications relay signals to other proteins to trigger more immediate responses than can be achieved through altered gene transcription, which might be especially important to time-urgent processes such as the execution of cell-cycle check points, chromosome segregation, or exit from mitosis. In addition, histone-modifying enzymes often have multiple nonhistone substrates, and coordination of activity toward different targets might direct signals both to and from chromatin.
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U2 - 10.1016/j.cell.2013.01.017
DO - 10.1016/j.cell.2013.01.017
M3 - Review article
C2 - 23375745
AN - SCOPUS:84874116331
SN - 0092-8674
VL - 152
SP - 685
EP - 689
JO - Cell
JF - Cell
IS - 4
ER -