Chronic myelomonocytic leukemia: Forefront of the field in 2015

Christopher B. Benton, Aziz Nazha, Naveen Pemmaraju, Guillermo Garcia-Manero

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Chronic myelomonocytic leukemia (CMML) includes components of both myelodysplastic syndrome and myeloproliferative neoplasms and is associated with a characteristic peripheral monocytosis. CMML is caused by the proliferation of an abnormal hematopoietic stem cell clone and may be influenced by microenvironmental changes. The disease is rare and has undergone revisions in its classification. We review the recent classification strategies as well as diagnostic criteria, focusing on CMML's genetic alterations and unique pathophysiology. We also discuss the latest molecular characterization of the disease, including how molecular factors affect current prognostic models. Finally, we focus on available treatment strategies, with a special emphasis on experimental and forthcoming therapies.

Original languageEnglish (US)
Pages (from-to)222-242
Number of pages21
JournalCritical Reviews in Oncology/Hematology
Volume95
Issue number2
DOIs
StatePublished - Aug 1 2015

Keywords

  • Chronic myelomonocytic leukemia
  • Myelodysplastic syndrome
  • Myeloproliferative neoplasms

ASJC Scopus subject areas

  • Hematology
  • Oncology

Fingerprint

Dive into the research topics of 'Chronic myelomonocytic leukemia: Forefront of the field in 2015'. Together they form a unique fingerprint.

Cite this