TY - JOUR
T1 - Chronic myelomonocytic leukemia
T2 - Forefront of the field in 2015
AU - Benton, Christopher B.
AU - Nazha, Aziz
AU - Pemmaraju, Naveen
AU - Garcia-Manero, Guillermo
N1 - Publisher Copyright:
© 2015 .
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Chronic myelomonocytic leukemia (CMML) includes components of both myelodysplastic syndrome and myeloproliferative neoplasms and is associated with a characteristic peripheral monocytosis. CMML is caused by the proliferation of an abnormal hematopoietic stem cell clone and may be influenced by microenvironmental changes. The disease is rare and has undergone revisions in its classification. We review the recent classification strategies as well as diagnostic criteria, focusing on CMML's genetic alterations and unique pathophysiology. We also discuss the latest molecular characterization of the disease, including how molecular factors affect current prognostic models. Finally, we focus on available treatment strategies, with a special emphasis on experimental and forthcoming therapies.
AB - Chronic myelomonocytic leukemia (CMML) includes components of both myelodysplastic syndrome and myeloproliferative neoplasms and is associated with a characteristic peripheral monocytosis. CMML is caused by the proliferation of an abnormal hematopoietic stem cell clone and may be influenced by microenvironmental changes. The disease is rare and has undergone revisions in its classification. We review the recent classification strategies as well as diagnostic criteria, focusing on CMML's genetic alterations and unique pathophysiology. We also discuss the latest molecular characterization of the disease, including how molecular factors affect current prognostic models. Finally, we focus on available treatment strategies, with a special emphasis on experimental and forthcoming therapies.
KW - Chronic myelomonocytic leukemia
KW - Myelodysplastic syndrome
KW - Myeloproliferative neoplasms
UR - http://www.scopus.com/inward/record.url?scp=84937518812&partnerID=8YFLogxK
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U2 - 10.1016/j.critrevonc.2015.03.002
DO - 10.1016/j.critrevonc.2015.03.002
M3 - Review article
C2 - 25869097
AN - SCOPUS:84937518812
SN - 1040-8428
VL - 95
SP - 222
EP - 242
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
IS - 2
ER -