TY - JOUR
T1 - Circulating fatty acids associated with advanced liver fibrosis and hepatocellular carcinoma in South Texas hispanics
AU - Jiao, Jingjing
AU - Kwan, Suet Ying
AU - Sabotta, Caroline M.
AU - Tanaka, Honami
AU - Veillon, Lucas
AU - Warmoes, Marc O.
AU - Lorenzi, Philip L.
AU - Wang, Ying
AU - Wei, Peng
AU - Hawk, Ernest T.
AU - Almeda, Jose Luis
AU - McCormick, Joseph B.
AU - Fisher-Hoch, Susan P.
AU - Beretta, Laura
N1 - Funding Information:
We thank Roc?o Uribe, Ivana Zavla, and Dr. Monica Betancourt-Garcia for the enrollment of CCHC participants and patients with HCC; Marcela Morris and Hugo Soriano for data support; and the participants from the Lower Rio Grande Valley who so willingly participated in this study. This research was supported in part by the MD Anderson Cancer Center SPORE in Hepatocellular Carcinoma Grant P50 CA217674 from the National Cancer Institute (NCI), and byNIH/NCI grants R01CA204665 and R01CA195524. The Metabolomics Core Facility was supported by Cancer Prevention and Research Institute of Texas grant RP130397 and NIH grants S10OD012304-01 and P30CA016672. The cohort was supported by an NIH/Center for Clinical and Translational Sciences, grant UL1 TR000371.
Funding Information:
This research was supported in part by the MD Anderson Cancer Center SPORE in Hepatocellular Carcinoma Grant P50 CA217674 from the National Cancer Institute (NCI), and by NIH/NCI grants R01CA204665 and R01CA195524. The Metabolomics Core Facility was supported by Cancer Prevention and Research Institute of Texas grant RP130397 and NIH grants S10OD012304–01 and P30CA016672. The cohort was supported by an NIH/Center for Clinical and Translational Sciences, grant UL1 TR000371.
Publisher Copyright:
© 2021 American Association for Cancer Research.
PY - 2021/9
Y1 - 2021/9
N2 - Background: Hispanics in South Texas have high rates of hepatocellular carcinoma (HCC) and nonalcoholic fatty liver disease (NAFLD). Liver fibrosis severity is the strongest predictive factor of NAFLD progression to HCC. We examined the association between free fatty acids (FA) and advanced liver fibrosis or HCC in this population. Methods: We quantified 45 FAs in plasma of 116 subjects of the Cameron County Hispanic Cohort, 15 Hispanics with HCC, and 56 first/second-degree relatives of Hispanics with HCC. Liver fibrosis was assessed by FibroScan. Results: Advanced liver fibrosis was significantly associated with low expression of very long chain (VLC) saturated FAs (SFA), odd chain SFAs, and VLC n-3 polyunsaturated FAs [PUFA; AOR; 95% confidence interval (CI), 10.4 (3.7-29.6); P < 0.001; 5.7 (2.2-15.2); P < 0.001; and 3.7 (1.5-9.3); P = 0.005]. VLC n3-PUFAs significantly improved the performance of the noninvasive markers for advanced fibrosis - APRI, FIB-4, and NFS. Plasma concentrations of VLC SFAs and VLC n-3 PUFAs were further reduced in patients with HCC. Low concentrations of these FAs were also observed in relatives of patients with HCC and in subjects with the PNPLA3 rs738409 homozygous genotype. Conclusions: Low plasma concentrations of VLC n-3 PUFAs and VLC SFAs were strongly associated with advanced liver fibrosis and HCC in this population. Genetic factors were associated with low concentrations of these FAs as well. Impact: These results have implications in identifying those at risk for liver fibrosis progression to HCC and in screening this population for advanced fibrosis. They also prompt the evaluation of VLC n-3 PUFA or VLC SFA supplementation to prevent cirrhosis and HCC.
AB - Background: Hispanics in South Texas have high rates of hepatocellular carcinoma (HCC) and nonalcoholic fatty liver disease (NAFLD). Liver fibrosis severity is the strongest predictive factor of NAFLD progression to HCC. We examined the association between free fatty acids (FA) and advanced liver fibrosis or HCC in this population. Methods: We quantified 45 FAs in plasma of 116 subjects of the Cameron County Hispanic Cohort, 15 Hispanics with HCC, and 56 first/second-degree relatives of Hispanics with HCC. Liver fibrosis was assessed by FibroScan. Results: Advanced liver fibrosis was significantly associated with low expression of very long chain (VLC) saturated FAs (SFA), odd chain SFAs, and VLC n-3 polyunsaturated FAs [PUFA; AOR; 95% confidence interval (CI), 10.4 (3.7-29.6); P < 0.001; 5.7 (2.2-15.2); P < 0.001; and 3.7 (1.5-9.3); P = 0.005]. VLC n3-PUFAs significantly improved the performance of the noninvasive markers for advanced fibrosis - APRI, FIB-4, and NFS. Plasma concentrations of VLC SFAs and VLC n-3 PUFAs were further reduced in patients with HCC. Low concentrations of these FAs were also observed in relatives of patients with HCC and in subjects with the PNPLA3 rs738409 homozygous genotype. Conclusions: Low plasma concentrations of VLC n-3 PUFAs and VLC SFAs were strongly associated with advanced liver fibrosis and HCC in this population. Genetic factors were associated with low concentrations of these FAs as well. Impact: These results have implications in identifying those at risk for liver fibrosis progression to HCC and in screening this population for advanced fibrosis. They also prompt the evaluation of VLC n-3 PUFA or VLC SFA supplementation to prevent cirrhosis and HCC.
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U2 - 10.1158/1055-9965.EPI-21-0183
DO - 10.1158/1055-9965.EPI-21-0183
M3 - Article
C2 - 34155064
AN - SCOPUS:85114189026
SN - 1055-9965
VL - 30
SP - 1643
EP - 1651
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 9
ER -