Clear cell adenocarcinoma of the urinary bladder: A short review

Adebowale J. Adeniran, Pheroze Tamboli

Research output: Contribution to journalShort surveypeer-review

34 Scopus citations

Abstract

In this short review, we discuss clear cell adenocarcinoma of the urinary bladder, a rare tumor that primarily affects women. The histogenesis of this neoplasm is uncertain; in some tumors the clinicopathologic and histologic features are suggestive of a müllerian origin. Clear cell adenocarcinoma consists of cells with abundant clear cytoplasm, arranged in solid, glandular, or tubulocystic patterns. These tumors are positive for pancytokeratin, cytokeratin 7, and CA 125 immunohistochemical stains. Patients typically present with gross hematuria, dysuria, and discharge. The natural history is poorly understood and patient outcomes remain unclear. Currently, surgery is the treatment of choice. Nephrogenic adenoma is the most important differential diagnostic consideration, followed by metastatic clear cell carcinoma.

Original languageEnglish (US)
Pages (from-to)987-991
Number of pages5
JournalArchives of Pathology and Laboratory Medicine
Volume133
Issue number6
StatePublished - Jun 2009

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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