Clinical analysis of second primary oral squamous cancer in patients with nasopharyngeal carcinoma after radiotherapy

Shimin Zhuang, Zhuming Guo, An-kui Yang, Quan Zhang, Shuwei Chen, Liping Wang, Ming Song

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the clinical characteristics of second primary oral squamous cancer (SPOSC) in nasopharyngeal carcinoma (NPC) patients after radiotherapy. The related prognostic factors are also investigated. Methods: Data of 12,121 NPC patients admitted to the Cancer Center of Sun Yat-Sen University during the period January 1990 to December 2005 were retrospectively analyzed. Of these, SPOSC occurred in 36 cases after radiotherapy for NPC. The Kaplan-Meier curve was used to calculate the accumulated survival rate, and multivariate analysis was performed in these patients using the Cox proportional hazard model. Results: Of the 36 SPOSC patients, 21 died during the follow-up. The overall 3, 5, and 10-year survival rates of the 36 patients who underwent SPOSC treatment were 38.9%, 22.2% and 11.1%, respectively. Of the 36 cases, SPOSC in the tongue occurred in 23 cases, SPOSC in the gum were found in 7 cases, and SPOSC in the palate were found in 3 cases. Lesions at the other sites were seen in the remaining 3 cases. The univariate analysis showed that the major prognostic factors influencing the survival of the SPOSC patients were tumor size, N stage, mode of treatment, and clinical TNM staging. The multivariate analysis for risk factors of the positive lymph node was the independent factor affecting the prognosis. Conclusion: There is a high risk of SPOSC in the tongue after radiotherapy of NPC. Tumor size, pathological N stage, and treatment method are the independent factors affecting survival. Vigilance for SPOSC should be maintained for 5 years after radiotherapy of NPC. Our data indicate that early diagnosis and combined therapy, with surgery as the first choice of treatment for SPOSC, may lead to better survival rate and prognosis.

Original languageEnglish (US)
JournalChinese Journal of Clinical Oncology
Volume38
Issue number17
DOIs
StatePublished - Sep 15 2011

Fingerprint

Mouth Neoplasms
Radiotherapy
Tongue Neoplasms
Survival Rate
Nasopharyngeal carcinoma
Multivariate Analysis
Therapeutics
Neoplasms
Survival
Palate
Neoplasm Staging
Gingiva
Solar System
Survival Analysis
Proportional Hazards Models
Early Diagnosis
Lymph Nodes

Keywords

  • Nasopharyngeal carcinoma
  • Oral squamous carcinoma
  • Second primary cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Clinical analysis of second primary oral squamous cancer in patients with nasopharyngeal carcinoma after radiotherapy. / Zhuang, Shimin; Guo, Zhuming; Yang, An-kui; Zhang, Quan; Chen, Shuwei; Wang, Liping; Song, Ming.

In: Chinese Journal of Clinical Oncology, Vol. 38, No. 17, 15.09.2011.

Research output: Contribution to journalArticle

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title = "Clinical analysis of second primary oral squamous cancer in patients with nasopharyngeal carcinoma after radiotherapy",
abstract = "Objective: To investigate the clinical characteristics of second primary oral squamous cancer (SPOSC) in nasopharyngeal carcinoma (NPC) patients after radiotherapy. The related prognostic factors are also investigated. Methods: Data of 12,121 NPC patients admitted to the Cancer Center of Sun Yat-Sen University during the period January 1990 to December 2005 were retrospectively analyzed. Of these, SPOSC occurred in 36 cases after radiotherapy for NPC. The Kaplan-Meier curve was used to calculate the accumulated survival rate, and multivariate analysis was performed in these patients using the Cox proportional hazard model. Results: Of the 36 SPOSC patients, 21 died during the follow-up. The overall 3, 5, and 10-year survival rates of the 36 patients who underwent SPOSC treatment were 38.9{\%}, 22.2{\%} and 11.1{\%}, respectively. Of the 36 cases, SPOSC in the tongue occurred in 23 cases, SPOSC in the gum were found in 7 cases, and SPOSC in the palate were found in 3 cases. Lesions at the other sites were seen in the remaining 3 cases. The univariate analysis showed that the major prognostic factors influencing the survival of the SPOSC patients were tumor size, N stage, mode of treatment, and clinical TNM staging. The multivariate analysis for risk factors of the positive lymph node was the independent factor affecting the prognosis. Conclusion: There is a high risk of SPOSC in the tongue after radiotherapy of NPC. Tumor size, pathological N stage, and treatment method are the independent factors affecting survival. Vigilance for SPOSC should be maintained for 5 years after radiotherapy of NPC. Our data indicate that early diagnosis and combined therapy, with surgery as the first choice of treatment for SPOSC, may lead to better survival rate and prognosis.",
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T1 - Clinical analysis of second primary oral squamous cancer in patients with nasopharyngeal carcinoma after radiotherapy

AU - Zhuang, Shimin

AU - Guo, Zhuming

AU - Yang, An-kui

AU - Zhang, Quan

AU - Chen, Shuwei

AU - Wang, Liping

AU - Song, Ming

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N2 - Objective: To investigate the clinical characteristics of second primary oral squamous cancer (SPOSC) in nasopharyngeal carcinoma (NPC) patients after radiotherapy. The related prognostic factors are also investigated. Methods: Data of 12,121 NPC patients admitted to the Cancer Center of Sun Yat-Sen University during the period January 1990 to December 2005 were retrospectively analyzed. Of these, SPOSC occurred in 36 cases after radiotherapy for NPC. The Kaplan-Meier curve was used to calculate the accumulated survival rate, and multivariate analysis was performed in these patients using the Cox proportional hazard model. Results: Of the 36 SPOSC patients, 21 died during the follow-up. The overall 3, 5, and 10-year survival rates of the 36 patients who underwent SPOSC treatment were 38.9%, 22.2% and 11.1%, respectively. Of the 36 cases, SPOSC in the tongue occurred in 23 cases, SPOSC in the gum were found in 7 cases, and SPOSC in the palate were found in 3 cases. Lesions at the other sites were seen in the remaining 3 cases. The univariate analysis showed that the major prognostic factors influencing the survival of the SPOSC patients were tumor size, N stage, mode of treatment, and clinical TNM staging. The multivariate analysis for risk factors of the positive lymph node was the independent factor affecting the prognosis. Conclusion: There is a high risk of SPOSC in the tongue after radiotherapy of NPC. Tumor size, pathological N stage, and treatment method are the independent factors affecting survival. Vigilance for SPOSC should be maintained for 5 years after radiotherapy of NPC. Our data indicate that early diagnosis and combined therapy, with surgery as the first choice of treatment for SPOSC, may lead to better survival rate and prognosis.

AB - Objective: To investigate the clinical characteristics of second primary oral squamous cancer (SPOSC) in nasopharyngeal carcinoma (NPC) patients after radiotherapy. The related prognostic factors are also investigated. Methods: Data of 12,121 NPC patients admitted to the Cancer Center of Sun Yat-Sen University during the period January 1990 to December 2005 were retrospectively analyzed. Of these, SPOSC occurred in 36 cases after radiotherapy for NPC. The Kaplan-Meier curve was used to calculate the accumulated survival rate, and multivariate analysis was performed in these patients using the Cox proportional hazard model. Results: Of the 36 SPOSC patients, 21 died during the follow-up. The overall 3, 5, and 10-year survival rates of the 36 patients who underwent SPOSC treatment were 38.9%, 22.2% and 11.1%, respectively. Of the 36 cases, SPOSC in the tongue occurred in 23 cases, SPOSC in the gum were found in 7 cases, and SPOSC in the palate were found in 3 cases. Lesions at the other sites were seen in the remaining 3 cases. The univariate analysis showed that the major prognostic factors influencing the survival of the SPOSC patients were tumor size, N stage, mode of treatment, and clinical TNM staging. The multivariate analysis for risk factors of the positive lymph node was the independent factor affecting the prognosis. Conclusion: There is a high risk of SPOSC in the tongue after radiotherapy of NPC. Tumor size, pathological N stage, and treatment method are the independent factors affecting survival. Vigilance for SPOSC should be maintained for 5 years after radiotherapy of NPC. Our data indicate that early diagnosis and combined therapy, with surgery as the first choice of treatment for SPOSC, may lead to better survival rate and prognosis.

KW - Nasopharyngeal carcinoma

KW - Oral squamous carcinoma

KW - Second primary cancer

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