Clinical and future applications of high intensity focused ultrasound in cancer

Osama Al-Bataineh, Jürgen Jenne, Peter Huber

Research output: Contribution to journalReview article

117 Citations (Scopus)

Abstract

High intensity focused ultrasound (HIFU) or focused ultrasound (FUS) is a promising modality to treat tumors in a complete, non invasive fashion where online image guidance and therapy control can be achieved by magnetic resonance imaging (MRI) or diagnostic ultrasound (US). In the last 10 years, the feasibility and the safety of HIFU have been tested in a growing number of clinical studies on several benign and malignant tumors of the prostate, breast, uterine, liver, kidney, pancreas, bone, and brain. For certain indications this new treatment principle is on its verge to become a serious alternative or adjunct to the standard treatment options of surgery, radiotherapy, gene therapy and chemotherapy in oncology. In addition to the now clinically available thermal ablation, in the future, focused ultrasound at much lower intensities may have the potential to become a major instrument to mediate drug and gene delivery for localized cancer treatment. We introduce the technology of MRI guided and ultrasound guided HIFU and present a critical overview of the clinical applications and results along with a discussion of future HIFU developments.

Original languageEnglish (US)
Pages (from-to)346-353
Number of pages8
JournalCancer treatment reviews
Volume38
Issue number5
DOIs
StatePublished - Aug 1 2012

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Neoplasms
Magnetic Resonance Imaging
Therapeutics
Genetic Therapy
Prostate
Pancreas
Ultrasonography
Radiotherapy
Hot Temperature
Breast Neoplasms
Technology
Kidney
Safety
Bone and Bones
Drug Therapy
Liver
Brain
Pharmaceutical Preparations
Genes
Clinical Studies

Keywords

  • Cancer treatment
  • HIFU
  • High intensity focused ultrasound
  • Thermal ablation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Clinical and future applications of high intensity focused ultrasound in cancer. / Al-Bataineh, Osama; Jenne, Jürgen; Huber, Peter.

In: Cancer treatment reviews, Vol. 38, No. 5, 01.08.2012, p. 346-353.

Research output: Contribution to journalReview article

Al-Bataineh, Osama ; Jenne, Jürgen ; Huber, Peter. / Clinical and future applications of high intensity focused ultrasound in cancer. In: Cancer treatment reviews. 2012 ; Vol. 38, No. 5. pp. 346-353.
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