Clinical and genetic features of lung squamous cell cancer in never-smokers

Yangle Huang, Rui Wang, Yunjian Pan, Yang Zhang, Hang Li, Chao Cheng, Difan Zheng, Shanbo Zheng, Yuan Li, Xuxia Shen, Haichuan Hu, Deng Cai, Shengfei Wang, Yawei Zhang, Jiaqing Xiang, Yihua Sun, Jie Zhang, Haiquan Chen

    Research output: Contribution to journalArticle

    11 Scopus citations


    To evaluate the importance of specific driver mutations to the development and outcome of lung squamous cell cancer (SQCC) in never-smokers, we assessed the clinicopathological characteristics and outcomes of 597 patients who underwent complete resection of SQCCs. In total, 88 (14.7%) never-smokers and 509 (85.3%) ever-smokers were compared. The never-smokers included more females (42.05% vs. 1.57%, P < 0.001) and more often had a personal history of malignant disease (9.09% vs. 2.36%, P = 0.003). The tumors of never-smokers were more often poorly differentiated (70.45% vs. 53.24%, P = 0.010) and more often contained oncogenic mutations (21.05% vs 11.05%, P = 0.023), particularly EGFR mutations (13.16% vs 3.40%, P = 0.001). Never-smokers also tended to have poorer OS than smokers. Our results suggest lung SQCCs in never-smokers are a subtype distinct from SQCCs occurring in smokers.

    Original languageEnglish (US)
    Pages (from-to)35979-35988
    Number of pages10
    Issue number24
    StatePublished - Jan 1 2016


    • Clinicopathological characteristics
    • Genetic features
    • Never-smoker
    • Squamous cell lung cancer

    ASJC Scopus subject areas

    • Oncology

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  • Cite this

    Huang, Y., Wang, R., Pan, Y., Zhang, Y., Li, H., Cheng, C., Zheng, D., Zheng, S., Li, Y., Shen, X., Hu, H., Cai, D., Wang, S., Zhang, Y., Xiang, J., Sun, Y., Zhang, J., & Chen, H. (2016). Clinical and genetic features of lung squamous cell cancer in never-smokers. Oncotarget, 7(24), 35979-35988.