Clinical and prognostic analysis of second primary squamous cell carcinoma of the tongue after radiotherapy for nasopharyngeal carcinoma

Chuanzheng Sun, Zedong Hu, Zhaoming Zhong, Yue Jiang, Ruimei Sun, Jimin Fei, Yan Xi, Xiaojiang Li, Ming Song, Wenhui Li, Qiuli Li

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We have investigated the clinical characteristics and prognostic factors of squamous cell carcinoma (SCC) of the tongue after definitive radiotherapy for nasopharyngeal carcinoma, and evaluated the effect of common therapeutic regimens for these patients. We retrospectively reviewed follow-up data for patients whose nasopharyngeal carcinoma had been treated by radiotherapy, and selected the 68 who had then developed SCC of the tongue, in the border of the tongue in half, and in the dorsum in 25 (37%). Eight of the 68 patients had clinical lymph node metastasis (12%), and 45 presented with stage I-II disease at the time of the diagnosis of the SCC (66%). Resection or radiotherapy alone was an effective treatment for patients with stage I-II SCC of the tongue, but patients with stage III-IV disease had a poor prognosis, despite being given multidisciplinary treatment. Multivariate analysis showed that the risk factors that independently influenced the survival of these patients were use of alcohol, recurrence of their nasopharyngeal carcinoma, the latency period, and the clinical TNM stage. Tongue SCC after radiotherapy was generally at an early stage and commonly occurred on the border or the dorsum of the tongue, with few lymph node metastases. Resection or radiotherapy is an effective treatment, and the risk factors that independently influenced the survival of patients indicate that improving the technique of radiotherapy and close follow-up after nasopharyngeal cancer are vitally important.

Original languageEnglish (US)
Pages (from-to)715-720
Number of pages6
JournalBritish Journal of Oral and Maxillofacial Surgery
Volume52
Issue number8
DOIs
StatePublished - Oct 1 2014

Fingerprint

Tongue
Squamous Cell Carcinoma
Radiotherapy
Lymph Nodes
Nasopharyngeal Neoplasms
Neoplasm Metastasis
Survival
Therapeutic Uses
Nasopharyngeal carcinoma
Therapeutics
Multivariate Analysis
Alcohols
Recurrence

Keywords

  • Latency period
  • Nasopharyngeal carcinoma
  • Radiotherapy
  • Second primary tumour
  • Tongue squamous cell carcinoma

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

Cite this

Clinical and prognostic analysis of second primary squamous cell carcinoma of the tongue after radiotherapy for nasopharyngeal carcinoma. / Sun, Chuanzheng; Hu, Zedong; Zhong, Zhaoming; Jiang, Yue; Sun, Ruimei; Fei, Jimin; Xi, Yan; Li, Xiaojiang; Song, Ming; Li, Wenhui; Li, Qiuli.

In: British Journal of Oral and Maxillofacial Surgery, Vol. 52, No. 8, 01.10.2014, p. 715-720.

Research output: Contribution to journalArticle

Sun, Chuanzheng ; Hu, Zedong ; Zhong, Zhaoming ; Jiang, Yue ; Sun, Ruimei ; Fei, Jimin ; Xi, Yan ; Li, Xiaojiang ; Song, Ming ; Li, Wenhui ; Li, Qiuli. / Clinical and prognostic analysis of second primary squamous cell carcinoma of the tongue after radiotherapy for nasopharyngeal carcinoma. In: British Journal of Oral and Maxillofacial Surgery. 2014 ; Vol. 52, No. 8. pp. 715-720.
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