Clinical features and outcomes of primary hepatic neuroendocrine carcinomas

Chan Hyuk Park, Joo Won Chung, Seon Jung Jang, Moon Jae Chung, Seungmin Bang, Seung Woo Park, Si Young Song, Jae Bock Chung, Jeong Youp Park

    Research output: Contribution to journalArticle

    34 Scopus citations


    Background and Aim: Primary hepatic neuroendocrine carcinomas (PHNECs) are extremely rare, with only about 150 cases having been reported in the English-language literature. Because of the rarity of PHNECs, its clinical features and treatment outcomes are not well understood. Here, we report our experiences with PHNECs. Methods: We identified patients diagnosed with PHNEC and analyzed their demographics, baseline laboratory data, tumor characteristics, treatment modalities and outcomes. Results: A total of 218 consecutive patients were identified with pathologically confirmed neuroendocrine carcinoma. Of these, 12 patients were diagnosed with PHNECs; the median age was 66.5years (range, 37 to 80years), and seven patients (58.3%) were male. Two patients who each had a single hepatic mass underwent curative surgical resection. One patient who was of inoperable status at the initial diagnosis because of multiple intrahepatic metastases showed a partial response after the ninth round of systemic chemotherapy and then underwent surgical resection. The median overall survival in the 12 patients was 16.5months (range, 0.7 to 41.7months). Three patients who underwent surgical treatment are alive without recurrence for 15.2months, 18.0months, and 36.9months, respectively. Conclusions: Primary hepatic neuroendocrine carcinoma should be considered as a possible differential diagnosis in the management of hepatic tumors. The liver can be the primary origin of neuroendocrine tumors, and if the tumors are diagnosed as primary hepatic neuroendocrine tumors, surgical resection must be considered for curative treatment.

    Original languageEnglish (US)
    Pages (from-to)1306-1311
    Number of pages6
    JournalJournal of Gastroenterology and Hepatology (Australia)
    Issue number8
    StatePublished - Aug 2012



    • Carcinoid tumor
    • Carcinoma
    • Neuroendocrine
    • Neuroendocrine tumors

    ASJC Scopus subject areas

    • Hepatology
    • Gastroenterology

    Cite this

    Park, C. H., Chung, J. W., Jang, S. J., Chung, M. J., Bang, S., Park, S. W., Song, S. Y., Chung, J. B., & Park, J. Y. (2012). Clinical features and outcomes of primary hepatic neuroendocrine carcinomas. Journal of Gastroenterology and Hepatology (Australia), 27(8), 1306-1311.