Clinical features and survival analysis of T1mic, a, bN0M0 breast cancer

Junnan Li, Xiaodong Liu, Zhongsheng Tong

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    3 Scopus citations

    Abstract

    Objective: To analyze the clinicopathological features and prognosis of T1mic, a, bN0M0 breast cancer. Methods: The clinical data and survival status of 4487 cases of operable breast cancer treated in our hospital from 2002 to 2005 were collected, including 372 cases with T1mic, a, bN0M0 breast cancers. These patients were divided into four subtypes: Luminal A, Luminal B, triple-negative and human epidermal growth factor receptor 2-positive. Disease-free survival and risk factors for recurrence were identified. Results: We identified 372 eligible patients. The median follow-up was 78 months (range: 5-106 months). Univariate analysis showed age, adjuvant endocrine therapy, hormonal receptor and human epidermal growth factor receptor 2 were prognostic factors. Multivariate analysis showed that hormonal receptor and human epidermal growth factor receptor 2 were prognostic factors. In the hormonal receptor-positive group, human epidermal growth factor receptor 2-positive patients (Luminal B) had a four times higher recurrence risk than human epidermal growth factor receptor 2 negative (Luminal A) patients. However, there was no statistically significant difference between hormonal receptor-negative groups (triple-negative and human epidermal growth factor receptor 2-positive). Conclusions: Hormonal receptor and human epidermal growth factor receptor 2 were independent factors of 5-year disease-free survival for patients with T1mic, a, bN0M0 breast cancer. The Luminal B group had a worse prognosis than the Luminal A group, but there was no statistically significant difference between triple-negative and human epidermal growth factor receptor 2-positive groups.

    Original languageEnglish (US)
    Article numberhys046
    Pages (from-to)471-476
    Number of pages6
    JournalJapanese journal of clinical oncology
    Volume42
    Issue number6
    DOIs
    StatePublished - Jun 1 2012

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    Keywords

    • Breast neoplasms
    • Prognosis
    • T1mic, a, bN0M0

    ASJC Scopus subject areas

    • Oncology
    • Radiology Nuclear Medicine and imaging
    • Cancer Research

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