Clinical outcomes after local field conformal reirradiation of patients with retropharyngeal nodal metastasis

Courtney Pollard; Theresa P. Nguyen; Sweet Ping Ng; Steven J. Frank; Adam S. Garden; Gary B. Gunn; Clifton D. Fuller; Beth M. Beadle; William H. Morrison; Shah J. Shah; He Wang; Sam Tung; Conjun Wang; Lawrence D. Ginsberg; Mark E. Zafereo; Erich M. Sturgis; Shirley Y. Su; Ehab Y. Hanna; David I. Rosenthal; Jack Phan

doi:10.1002/hed.24872

Clinical outcomes after local field conformal reirradiation of patients with retropharyngeal nodal metastasis

Courtney Pollard, Theresa P. Nguyen, Sweet Ping Ng, Steven J. Frank, Adam S. Garden, Gary B. Gunn, Clifton D. Fuller, Beth M. Beadle, William H. Morrison, Shah J. Shah, He Wang, Sam Tung, Conjun Wang, Lawrence D. Ginsberg, Mark E. Zafereo, Erich M. Sturgis, Shirley Y. Su, Ehab Y. Hanna, David I. Rosenthal, Jack Phan

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background: The purpose of this study was to present our experience with retropharyngeal node reirradiation using highly conformal radiotherapy (RT). Methods: A retrospective screen of 2504 consecutively irradiated patients with head and neck malignancies between 2005 and 2015 identified 19 patients who underwent reirradiation for retropharyngeal node metastasis. Clinical and toxicity outcomes were assessed in these patients. Results: Thirteen patients (68%) had squamous cell carcinoma. Eleven patients (58%) received conventionally fractionated intensity-modulated radiotherapy (IMRT) or proton therapy, and 8 patients (42%) received single-fractionated or hypofractionated stereotactic RT. Fourteen patients (74%) received chemotherapy. Median follow-up was 14.7 months. The 1-year local control, locoregional control, overall survival, and progression-free survival rates were 100%, 94%, 92%, and 92%, respectively. Three patients (16%) experienced acute grade 3 toxicity and occurred in those treated with IMRT. There was no late grade ≥3 toxicity. Conclusion: Retropharyngeal node reirradiation with conformal therapy is well tolerated and associated with excellent short-term disease control.

Original language	English (US)
Pages (from-to)	2079-2087
Number of pages	9
Journal	Head and Neck
Volume	39
Issue number	10
DOIs	https://doi.org/10.1002/hed.24872
State	Published - Oct 2017

Keywords

conformal radiotherapy
recurrent
reirradiation
retropharyngeal
stereotactic body radiotherapy

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.24872

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Pollard, C., Nguyen, T. P., Ng, S. P., Frank, S. J., Garden, A. S., Gunn, G. B., Fuller, C. D., Beadle, B. M., Morrison, W. H., Shah, S. J., Wang, H., Tung, S., Wang, C., Ginsberg, L. D., Zafereo, M. E., Sturgis, E. M., Su, S. Y., Hanna, E. Y., Rosenthal, D. I., & Phan, J. (2017). Clinical outcomes after local field conformal reirradiation of patients with retropharyngeal nodal metastasis. Head and Neck, 39(10), 2079-2087. https://doi.org/10.1002/hed.24872

Pollard, C, Nguyen, TP, Ng, SP, Frank, SJ , Garden, AS , Gunn, GB , Fuller, CD, Beadle, BM, Morrison, WH, Shah, SJ, Wang, H, Tung, S, Wang, C, Ginsberg, LD, Zafereo, ME, Sturgis, EM, Su, SY , Hanna, EY , Rosenthal, DI & Phan, J 2017, 'Clinical outcomes after local field conformal reirradiation of patients with retropharyngeal nodal metastasis', Head and Neck, vol. 39, no. 10, pp. 2079-2087. https://doi.org/10.1002/hed.24872

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abstract = "Background: The purpose of this study was to present our experience with retropharyngeal node reirradiation using highly conformal radiotherapy (RT). Methods: A retrospective screen of 2504 consecutively irradiated patients with head and neck malignancies between 2005 and 2015 identified 19 patients who underwent reirradiation for retropharyngeal node metastasis. Clinical and toxicity outcomes were assessed in these patients. Results: Thirteen patients (68%) had squamous cell carcinoma. Eleven patients (58%) received conventionally fractionated intensity-modulated radiotherapy (IMRT) or proton therapy, and 8 patients (42%) received single-fractionated or hypofractionated stereotactic RT. Fourteen patients (74%) received chemotherapy. Median follow-up was 14.7 months. The 1-year local control, locoregional control, overall survival, and progression-free survival rates were 100%, 94%, 92%, and 92%, respectively. Three patients (16%) experienced acute grade 3 toxicity and occurred in those treated with IMRT. There was no late grade ≥3 toxicity. Conclusion: Retropharyngeal node reirradiation with conformal therapy is well tolerated and associated with excellent short-term disease control.",

keywords = "conformal radiotherapy, recurrent, reirradiation, retropharyngeal, stereotactic body radiotherapy",

author = "Courtney Pollard and Nguyen, {Theresa P.} and Ng, {Sweet Ping} and Frank, {Steven J.} and Garden, {Adam S.} and Gunn, {Gary B.} and Fuller, {Clifton D.} and Beadle, {Beth M.} and Morrison, {William H.} and Shah, {Shah J.} and He Wang and Sam Tung and Conjun Wang and Ginsberg, {Lawrence D.} and Zafereo, {Mark E.} and Sturgis, {Erich M.} and Su, {Shirley Y.} and Hanna, {Ehab Y.} and Rosenthal, {David I.} and Jack Phan",

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doi = "10.1002/hed.24872",

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T1 - Clinical outcomes after local field conformal reirradiation of patients with retropharyngeal nodal metastasis

AU - Pollard, Courtney

AU - Nguyen, Theresa P.

AU - Ng, Sweet Ping

AU - Frank, Steven J.

AU - Garden, Adam S.

AU - Gunn, Gary B.

AU - Fuller, Clifton D.

AU - Beadle, Beth M.

AU - Morrison, William H.

AU - Shah, Shah J.

AU - Wang, He

AU - Tung, Sam

AU - Wang, Conjun

AU - Ginsberg, Lawrence D.

AU - Zafereo, Mark E.

AU - Sturgis, Erich M.

AU - Su, Shirley Y.

AU - Hanna, Ehab Y.

AU - Rosenthal, David I.

AU - Phan, Jack

PY - 2017/10

Y1 - 2017/10

N2 - Background: The purpose of this study was to present our experience with retropharyngeal node reirradiation using highly conformal radiotherapy (RT). Methods: A retrospective screen of 2504 consecutively irradiated patients with head and neck malignancies between 2005 and 2015 identified 19 patients who underwent reirradiation for retropharyngeal node metastasis. Clinical and toxicity outcomes were assessed in these patients. Results: Thirteen patients (68%) had squamous cell carcinoma. Eleven patients (58%) received conventionally fractionated intensity-modulated radiotherapy (IMRT) or proton therapy, and 8 patients (42%) received single-fractionated or hypofractionated stereotactic RT. Fourteen patients (74%) received chemotherapy. Median follow-up was 14.7 months. The 1-year local control, locoregional control, overall survival, and progression-free survival rates were 100%, 94%, 92%, and 92%, respectively. Three patients (16%) experienced acute grade 3 toxicity and occurred in those treated with IMRT. There was no late grade ≥3 toxicity. Conclusion: Retropharyngeal node reirradiation with conformal therapy is well tolerated and associated with excellent short-term disease control.

AB - Background: The purpose of this study was to present our experience with retropharyngeal node reirradiation using highly conformal radiotherapy (RT). Methods: A retrospective screen of 2504 consecutively irradiated patients with head and neck malignancies between 2005 and 2015 identified 19 patients who underwent reirradiation for retropharyngeal node metastasis. Clinical and toxicity outcomes were assessed in these patients. Results: Thirteen patients (68%) had squamous cell carcinoma. Eleven patients (58%) received conventionally fractionated intensity-modulated radiotherapy (IMRT) or proton therapy, and 8 patients (42%) received single-fractionated or hypofractionated stereotactic RT. Fourteen patients (74%) received chemotherapy. Median follow-up was 14.7 months. The 1-year local control, locoregional control, overall survival, and progression-free survival rates were 100%, 94%, 92%, and 92%, respectively. Three patients (16%) experienced acute grade 3 toxicity and occurred in those treated with IMRT. There was no late grade ≥3 toxicity. Conclusion: Retropharyngeal node reirradiation with conformal therapy is well tolerated and associated with excellent short-term disease control.

KW - conformal radiotherapy

KW - recurrent

KW - reirradiation

KW - retropharyngeal

KW - stereotactic body radiotherapy

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Clinical outcomes after local field conformal reirradiation of patients with retropharyngeal nodal metastasis

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