Clinical significance of Bcl-6 expression in young DLBCL patients with Myc+ or Bcl-2+Myc+

Linyu Li, Tingting Zhang, Xuhan Zhang, Lanfang Li, Lihua Qiu, Zhengzi Qian, Xianming Liu, Lixia Feng, Bin Meng, Yi Pan, Xiubao Ren, Xianhuo Wang, Huilai Zhang

    Research output: Contribution to journalArticle

    Abstract

    Objective: To investigate the expression of Bcl-6 in newly diagnosed and young patients with diffuse large B cell lymphoma (DLBCL), and to further explore its clinical significance in young DLBCL patients with Myc positive expression (Myc+) or Bcl-2 and Myc positive expressions (Bcl-2+Myc+). Methods: Immunohistochemical (IHC) staining was used to detect the expressions of Bcl-6, Myc and Bcl-2 in 116 newly diagnosed and young patients with DLBCL, and the complete clinical and pathological data were collected. The relationship between the expression levels of Bcl-6 protein and the prognosis of young DLBCL patients with Myc+ and Bcl-2+Myc+ was retrospectively analyzed. Results: There was no significantly correlation between the expression of Bcl-6 alone and the prognosis of young DLBCL patients (P > 0.05). However, for the DLBCL patients with Myc+, the prognosis in Bcl-6 negative (Bcl-6) group was worse than that in Bcl-6 positive (Bcl-6+) group (P < 0.05). Furthermore, the multivariate COX regression analysis showed that Bcl-6Myc+ expression was a significant independent factor of adverse prognosis except for the international prognostic index (IPI) (P < 0.05). Meanwhile, the prognosis of DLBLC patients with Bcl-6Bcl-2+Myc+ was significantly worse than that of the patients with Bcl-6+Bcl-2+Myc+ (P < 0.05). Conclusion: Bcl-6 negative expression can increase the risk of poor prognosis in young DLBCL patients with Myc+ or Bcl-2+Myc+.

    Original languageEnglish (US)
    Article number1000-7431(2018)09-0858-08
    Pages (from-to)858-865
    Number of pages8
    JournalTumor
    Volume38
    Issue number9
    DOIs
    StatePublished - Sep 1 2018

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    Keywords

    • Bcl-2
    • Bcl-6
    • Diffuse
    • Immuno-histochemistry
    • Large B cell
    • Lymphoma
    • Myc
    • Prognosis

    ASJC Scopus subject areas

    • Epidemiology
    • Oncology
    • Cancer Research

    Cite this

    Li, L., Zhang, T., Zhang, X., Li, L., Qiu, L., Qian, Z., Liu, X., Feng, L., Meng, B., Pan, Y., Ren, X., Wang, X., & Zhang, H. (2018). Clinical significance of Bcl-6 expression in young DLBCL patients with Myc+ or Bcl-2+Myc+ Tumor, 38(9), 858-865. [1000-7431(2018)09-0858-08]. https://doi.org/10.3781/j.issn.1000-7431.2018.33.169