Objective: This study aims to investigate the correlation between the expression of FoxP3, TGF-β 1, and epithelial-mesenchymal transition EMT in breast cancer and to determine the clinical significance of FoxP3. Methods: The expression of FoxP3, TGF-β 1, E-Cadherin, N-Cadherin, Vimentin, and Fibronectin protein were detected in the cancer cells of 74 cases with breast carcinoma via immunohistochemistry. The correlation of FoxP3 protein with clinico-pathologic features of breast carcinoma and the relationships among the expressions of FoxP3, TGF-β 1, and epithelial-mesenchymal transition EMT were analyzed. Results: The expression rates of FoxP3, TGF-β 1, and EMT are 36.5% (27/74), 39.2% (29/74), and 40.5% (30/74), respectively. The FoxP3 protein expression in breast cancer is correlated with lymph node metastasis (P<0.05) but not with other clinico-pathological features (P>0.05). The expression of FoxP3 is also correlated with the expression of TGF-β 1. Furthermore, TGF-β 1 can induce EMT (P<0.05). Conclusion: The expression of FoxP3 is correlated with lymph node metastasis and EMT in breast cancer. Therefore, FoxP3 may be a marker for predicting metastasis.
- Breast cancer
- Epithelial-mesenchymal transition
- TGF-β 1
ASJC Scopus subject areas
- Cancer Research