Clinicopathological features related to survival in adenocarcinoma of the Vaterian system in a Mexican population

Roberto Herrera-Goepfert, Giovanny Soca-Chafre, Samuel Almeida-Navarro, Angelica Montiel

Research output: Contribution to journalArticle

Abstract

Adenocarcinomas of the ampulla of Vater account for 0.5% of malignant neoplasms of the gastrointestinal tract and 6% to 20% of malignant periampullary neoplasms, with most patients being candidates for elective surgery. Our objective was to evaluate the clinicopathological prognostic factors of ampullary adenocarcinomas after surgical resection in a Mexican population. From the records of the Department of Pathology at the Instituto Nacional de Cancerología, México, cases diagnosed as adenocarcinomas of the ampulla of Vater were selected over a period of 11 years, from January 2005 to September 2015. Cases with a pancreaticoduodenectomy report were included, and from each case, demographic and pathological data of the surgical specimen were obtained. Univariate and multivariate statistical analyses were performed using the log-rank test and Cox regression. Of 157 cases diagnosed as ampullary adenocarcinomas, 104 patients were excluded as not eligible for surgical treatment at the time of diagnosis. In the remaining 53 patients, a pancreaticoduodenectomy was performed. The mean age of the entire group was 55.4 years, and most were men. Intestinal-type adenocarcinomas were more frequent (77.4%) than pancreatobiliary-type (15.1%), with most being without perineural invasion, well to moderately differentiated, and less than 3 cm in size. Lymph node metastasis and age greater than 65 years had a negative impact on overall survival of the patients. The most convenient classification of malignant epithelial tumors of the Vaterian system is according to the histopathologic phenotype grouped into intestinal-, pancreatobiliary-, and mixed-type adenocarcinomas, as well as uncommon variants.

LanguageEnglish (US)
Pages68-76
Number of pages9
JournalHuman Pathology
Volume83
DOIs
StatePublished - Jan 1 2019

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Adenocarcinoma
Survival
Population
Ampulla of Vater
Pancreaticoduodenectomy
Mexico
Gastrointestinal Tract
Neoplasms
Multivariate Analysis
Age Groups
Lymph Nodes
Demography
Pathology
Neoplasm Metastasis
Carcinoma
Phenotype
Therapeutics

Keywords

  • Adenocarcinoma
  • Ampulla of Vater
  • Intestinal type
  • Pancreaticoduodenectomy
  • Pancreatobiliary type
  • Vaterian system

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Clinicopathological features related to survival in adenocarcinoma of the Vaterian system in a Mexican population. / Herrera-Goepfert, Roberto; Soca-Chafre, Giovanny; Almeida-Navarro, Samuel; Montiel, Angelica.

In: Human Pathology, Vol. 83, 01.01.2019, p. 68-76.

Research output: Contribution to journalArticle

Herrera-Goepfert, Roberto ; Soca-Chafre, Giovanny ; Almeida-Navarro, Samuel ; Montiel, Angelica. / Clinicopathological features related to survival in adenocarcinoma of the Vaterian system in a Mexican population. In: Human Pathology. 2019 ; Vol. 83. pp. 68-76.
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