Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia

Simona Colla; Gabriella Sammarelli; Monica Crugnola; Stefano Ascani; Elena Sabbatini; Sabrina Bonomini; Magda Hojden; Luisa Craviotto; Isabel De Celis; Francesca Morandi; Cecilia Caramatti; Vittorio Rizzoli; Nicola Giuliani

doi:10.1111/j.1600-0609.2004.00222.x

Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia

Simona Colla
, Gabriella Sammarelli
, Monica Crugnola
, Stefano Ascani
, Elena Sabbatini
, Sabrina Bonomini
, Magda Hojden
, Luisa Craviotto
, Isabel De Celis
, Francesca Morandi
, Cecilia Caramatti
, Vittorio Rizzoli
, Nicola Giuliani

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In this study, we describe an extremely rare case of co-existence of a Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. A morphological, immunophenotypical and cytogenetic study has been performed to characterize the case and in order to identify the origin of two disorders. After the failure of the conventional therapy, the patient was treated with Imatinib with a complete hematological and cytogenetic response and a marked reduction of bone marrow fibrosis.

Original language	English (US)
Pages (from-to)	361-365
Number of pages	5
Journal	European Journal of Haematology
Volume	72
Issue number	5
DOIs	https://doi.org/10.1111/j.1600-0609.2004.00222.x
State	Published - May 2004
Externally published	Yes

Keywords

Chronic lymphocytic leukemia
Chronic myeloid leukemia
Imatinib
Megakaryoblast
Philadelphia chromosome

ASJC Scopus subject areas

Hematology

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10.1111/j.1600-0609.2004.00222.x

Cite this

Colla, S., Sammarelli, G., Crugnola, M., Ascani, S., Sabbatini, E., Bonomini, S., Hojden, M., Craviotto, L., De Celis, I., Morandi, F., Caramatti, C., Rizzoli, V., & Giuliani, N. (2004). Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. European Journal of Haematology, 72(5), 361-365. https://doi.org/10.1111/j.1600-0609.2004.00222.x

Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. / Colla, Simona; Sammarelli, Gabriella; Crugnola, Monica et al.
In: European Journal of Haematology, Vol. 72, No. 5, 05.2004, p. 361-365.

Research output: Contribution to journal › Article › peer-review

Colla, S, Sammarelli, G, Crugnola, M, Ascani, S, Sabbatini, E, Bonomini, S, Hojden, M, Craviotto, L, De Celis, I, Morandi, F, Caramatti, C, Rizzoli, V & Giuliani, N 2004, 'Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia', European Journal of Haematology, vol. 72, no. 5, pp. 361-365. https://doi.org/10.1111/j.1600-0609.2004.00222.x

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abstract = "In this study, we describe an extremely rare case of co-existence of a Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. A morphological, immunophenotypical and cytogenetic study has been performed to characterize the case and in order to identify the origin of two disorders. After the failure of the conventional therapy, the patient was treated with Imatinib with a complete hematological and cytogenetic response and a marked reduction of bone marrow fibrosis.",

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AU - Ascani, Stefano

AU - Sabbatini, Elena

AU - Bonomini, Sabrina

AU - Hojden, Magda

AU - Craviotto, Luisa

AU - De Celis, Isabel

AU - Morandi, Francesca

AU - Caramatti, Cecilia

AU - Rizzoli, Vittorio

AU - Giuliani, Nicola

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KW - Chronic lymphocytic leukemia

KW - Chronic myeloid leukemia

KW - Imatinib

KW - Megakaryoblast

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Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia

Abstract

Keywords

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