Coincidental Expression of Classic Hodgkin Lymphoma and Neurofibromatosis Type i and Literature Review

Trevor B. Cabrera; Wei Wang; Sireesha Yedururi; John M. Slopis; Raphael E. Steiner; Michael E. Rytting; Branko Cuglievan

doi:10.1097/MPH.0000000000001811

Coincidental Expression of Classic Hodgkin Lymphoma and Neurofibromatosis Type i and Literature Review

Trevor B. Cabrera, Wei Wang, Sireesha Yedururi, John M. Slopis, Raphael E. Steiner, Michael E. Rytting, Branko Cuglievan

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Neurofibromatosis Type 1 (NF1) is a genetic disorder with an incidence of 1 in 2600 to 3000 individuals. It is a clinical diagnosis characterized by café-au-lait macules, neurofibromas, and axillary and/or groin freckling. Because of genetic mutations in the NF1 gene affecting the Ras/mitogen-activated protein kinase pathway, there is also risk of associated soft tissue sarcomas and hematologic malignancies. However, reports of classic Hodgkin lymphoma in patients with NF1 are sparse. We report an adolescent with NF1 who developed classic Hodgkin lymphoma. Although there is an unclear association between mutations in the NF1 gene and classic Hodgkin lymphoma, further studies are warranted.

Original language	English (US)
Pages (from-to)	E535-E538
Journal	Journal of Pediatric Hematology/Oncology
Volume	43
Issue number	4
DOIs	https://doi.org/10.1097/MPH.0000000000001811
State	Published - May 2021

Keywords

HL
Hodgkin
MAPK
NF
Ras
lymphoma
neurofibromatosis

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1097/MPH.0000000000001811

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title = "Coincidental Expression of Classic Hodgkin Lymphoma and Neurofibromatosis Type i and Literature Review",

abstract = "Neurofibromatosis Type 1 (NF1) is a genetic disorder with an incidence of 1 in 2600 to 3000 individuals. It is a clinical diagnosis characterized by caf{\'e}-au-lait macules, neurofibromas, and axillary and/or groin freckling. Because of genetic mutations in the NF1 gene affecting the Ras/mitogen-activated protein kinase pathway, there is also risk of associated soft tissue sarcomas and hematologic malignancies. However, reports of classic Hodgkin lymphoma in patients with NF1 are sparse. We report an adolescent with NF1 who developed classic Hodgkin lymphoma. Although there is an unclear association between mutations in the NF1 gene and classic Hodgkin lymphoma, further studies are warranted.",

keywords = "HL, Hodgkin, MAPK, NF, Ras, lymphoma, neurofibromatosis",

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AU - Cabrera, Trevor B.

AU - Wang, Wei

AU - Yedururi, Sireesha

AU - Slopis, John M.

AU - Steiner, Raphael E.

AU - Rytting, Michael E.

AU - Cuglievan, Branko

PY - 2021/5

Y1 - 2021/5

N2 - Neurofibromatosis Type 1 (NF1) is a genetic disorder with an incidence of 1 in 2600 to 3000 individuals. It is a clinical diagnosis characterized by café-au-lait macules, neurofibromas, and axillary and/or groin freckling. Because of genetic mutations in the NF1 gene affecting the Ras/mitogen-activated protein kinase pathway, there is also risk of associated soft tissue sarcomas and hematologic malignancies. However, reports of classic Hodgkin lymphoma in patients with NF1 are sparse. We report an adolescent with NF1 who developed classic Hodgkin lymphoma. Although there is an unclear association between mutations in the NF1 gene and classic Hodgkin lymphoma, further studies are warranted.

AB - Neurofibromatosis Type 1 (NF1) is a genetic disorder with an incidence of 1 in 2600 to 3000 individuals. It is a clinical diagnosis characterized by café-au-lait macules, neurofibromas, and axillary and/or groin freckling. Because of genetic mutations in the NF1 gene affecting the Ras/mitogen-activated protein kinase pathway, there is also risk of associated soft tissue sarcomas and hematologic malignancies. However, reports of classic Hodgkin lymphoma in patients with NF1 are sparse. We report an adolescent with NF1 who developed classic Hodgkin lymphoma. Although there is an unclear association between mutations in the NF1 gene and classic Hodgkin lymphoma, further studies are warranted.

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KW - Hodgkin

KW - MAPK

KW - NF

KW - Ras

KW - lymphoma

KW - neurofibromatosis

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Coincidental Expression of Classic Hodgkin Lymphoma and Neurofibromatosis Type i and Literature Review

Abstract

Keywords

ASJC Scopus subject areas

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