Collapsing the tumor ecosystem: Preventing adaptive response to treatment by inhibiting transcription

Alessandro Carugo; Giulio F. Draetta

doi:10.1158/2159-8290.CD-17-1245

Collapsing the tumor ecosystem: Preventing adaptive response to treatment by inhibiting transcription

Alessandro Carugo, Giulio F. Draetta

Genomic Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Adaptation and resistance to treatment are the results of a multitude of (epi)genetic events unmasked or directly triggered by therapies targeting the genetic driver(s) of a dominant cell population within a tumor mass. Rusan and colleagues report that drug-tolerant cells are sensitive to THZ1, a dual CDK7/12 inhibitor, which, by impairing the transcriptional machinery, can prevent cellular rewiring to survive therapeutic attack.

Original language	English (US)
Pages (from-to)	17-19
Number of pages	3
Journal	Cancer discovery
Volume	8
Issue number	1
DOIs	https://doi.org/10.1158/2159-8290.CD-17-1245
State	Published - Jan 2018

ASJC Scopus subject areas

Oncology

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10.1158/2159-8290.CD-17-1245

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abstract = "Adaptation and resistance to treatment are the results of a multitude of (epi)genetic events unmasked or directly triggered by therapies targeting the genetic driver(s) of a dominant cell population within a tumor mass. Rusan and colleagues report that drug-tolerant cells are sensitive to THZ1, a dual CDK7/12 inhibitor, which, by impairing the transcriptional machinery, can prevent cellular rewiring to survive therapeutic attack.",

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Collapsing the tumor ecosystem: Preventing adaptive response to treatment by inhibiting transcription

Abstract

ASJC Scopus subject areas

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