TY - JOUR
T1 - Collision tumor of the kidney composed of clear cell carcinoma and collecting duct carcinoma
T2 - Report of a case with unusual morphology and clinical follow-up
AU - Burch-Smith, Rhonda
AU - Tannir, Nizar M.
AU - Resetkova, Erika
AU - Tamboli, Pheroze
AU - Rao, Priya
PY - 2014
Y1 - 2014
N2 - We report the case of a 67-year-old female who presented with a large renal mass. Gross examination of the nephrectomy specimen demonstrated a 6-cm renal mass that invaded into the renal sinus and perinephric fat. Histologic examination revealed two distinct tumor types. The first type was a conventional (clear cell) renal cell carcinoma that was of low nuclear grade and comprised the minority of the overall tumor. The second type was a high-grade collecting duct carcinoma with glandular/tubular differentiation and composed the majority of the tumor. Immunohistochemical studies demonstrated distinctive patterns of the two tumor types, thus confirming two distinct lineages. Five months postoperatively, the patient developed metastasis to the lungs and right hilar lymph node region. A fine needle aspiration of a lung nodule demonstrated a metastatic, poorly differentiated carcinoma, similar to the collecting duct carcinoma component in the kidney. Collision tumors of the kidney are rare with fewer than 10 cases reported in the literature. Our report further expands the spectrum of this rare phenomenon.
AB - We report the case of a 67-year-old female who presented with a large renal mass. Gross examination of the nephrectomy specimen demonstrated a 6-cm renal mass that invaded into the renal sinus and perinephric fat. Histologic examination revealed two distinct tumor types. The first type was a conventional (clear cell) renal cell carcinoma that was of low nuclear grade and comprised the minority of the overall tumor. The second type was a high-grade collecting duct carcinoma with glandular/tubular differentiation and composed the majority of the tumor. Immunohistochemical studies demonstrated distinctive patterns of the two tumor types, thus confirming two distinct lineages. Five months postoperatively, the patient developed metastasis to the lungs and right hilar lymph node region. A fine needle aspiration of a lung nodule demonstrated a metastatic, poorly differentiated carcinoma, similar to the collecting duct carcinoma component in the kidney. Collision tumors of the kidney are rare with fewer than 10 cases reported in the literature. Our report further expands the spectrum of this rare phenomenon.
KW - Clear cell carcinoma
KW - Collecting duct carcinoma
KW - Collision tumor
KW - Renal cell carcinoma
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U2 - 10.5732/cjc.013.10155
DO - 10.5732/cjc.013.10155
M3 - Article
C2 - 24589208
AN - SCOPUS:84903883508
SN - 1000-467X
VL - 33
SP - 351
EP - 355
JO - Chinese Journal of Cancer
JF - Chinese Journal of Cancer
IS - 7
ER -