Colorectal cancer in mice genetically deficient in the mucin Muc2

Anna Velcich; Wan Cai Yang; Joerg Heyer; Alessandra Fragale; Courtney Nicholas; Stephanie Viani; Raju Kucherlapati; Martin Lipkin; Kan Yang; Leonard Augenlicht

doi:10.1126/science.1069094

Colorectal cancer in mice genetically deficient in the mucin Muc2

Anna Velcich, Wan Cai Yang, Joerg Heyer, Alessandra Fragale, Courtney Nicholas, Stephanie Viani, Raju Kucherlapati, Martin Lipkin, Kan Yang, Leonard Augenlicht

Thoracic Head & Neck Medical Oncology

Research output: Contribution to journal › Article › peer-review

763 Scopus citations

Abstract

The gastrointestinal tract is lined by a layer of mucus comprised of highly glycosylated proteins called mucins. To evaluate the importance of mucin in intestinal carcinogenesis, we constructed mice genetically deficient in Muc2, the most abundant secreted gastrointestinal mucin. Muc2^-/- mice displayed aberrant intestinal crypt morphology and altered cell maturation and migration. Most notably, the mice frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors. Thus, Muc2 is involved in the suppression of colorectal31 cancer.

Original language	English (US)
Pages (from-to)	1726-1729
Number of pages	4
Journal	Science
Volume	295
Issue number	5560
DOIs	https://doi.org/10.1126/science.1069094
State	Published - Mar 1 2002

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title = "Colorectal cancer in mice genetically deficient in the mucin Muc2",

abstract = "The gastrointestinal tract is lined by a layer of mucus comprised of highly glycosylated proteins called mucins. To evaluate the importance of mucin in intestinal carcinogenesis, we constructed mice genetically deficient in Muc2, the most abundant secreted gastrointestinal mucin. Muc2-/- mice displayed aberrant intestinal crypt morphology and altered cell maturation and migration. Most notably, the mice frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors. Thus, Muc2 is involved in the suppression of colorectal31 cancer.",

author = "Anna Velcich and Yang, {Wan Cai} and Joerg Heyer and Alessandra Fragale and Courtney Nicholas and Stephanie Viani and Raju Kucherlapati and Martin Lipkin and Kan Yang and Leonard Augenlicht",

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AU - Velcich, Anna

AU - Yang, Wan Cai

AU - Heyer, Joerg

AU - Fragale, Alessandra

AU - Nicholas, Courtney

AU - Viani, Stephanie

AU - Kucherlapati, Raju

AU - Lipkin, Martin

AU - Yang, Kan

AU - Augenlicht, Leonard

PY - 2002/3/1

Y1 - 2002/3/1

N2 - The gastrointestinal tract is lined by a layer of mucus comprised of highly glycosylated proteins called mucins. To evaluate the importance of mucin in intestinal carcinogenesis, we constructed mice genetically deficient in Muc2, the most abundant secreted gastrointestinal mucin. Muc2-/- mice displayed aberrant intestinal crypt morphology and altered cell maturation and migration. Most notably, the mice frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors. Thus, Muc2 is involved in the suppression of colorectal31 cancer.

AB - The gastrointestinal tract is lined by a layer of mucus comprised of highly glycosylated proteins called mucins. To evaluate the importance of mucin in intestinal carcinogenesis, we constructed mice genetically deficient in Muc2, the most abundant secreted gastrointestinal mucin. Muc2-/- mice displayed aberrant intestinal crypt morphology and altered cell maturation and migration. Most notably, the mice frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors. Thus, Muc2 is involved in the suppression of colorectal31 cancer.

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Colorectal cancer in mice genetically deficient in the mucin Muc2

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