TY - JOUR
T1 - Combination chemoimmunotherapy of metastatic breast cancer with 5‐fluorouracil, adriamycin, cyclophosphamide, and BCG
AU - Hortobagyi, Gabriel N.
AU - Gutterman, Jordan U.
AU - Blumenschein, George R.
AU - Tashima, Charles K.
AU - Burgess, Michael A.
AU - Einhorn, Lawrence
AU - Buzdar, Aman U.
AU - Richman, Stephen P.
AU - Hersh, Evan M.
PY - 1979/11
Y1 - 1979/11
N2 - One hundred five patients with metastatic breast cancer were treated with 5‐fluorouracil, Adriamycin, cyclophosphamide and BCG (FAC‐BCG). The results were compared to those observed in a group of 44 patients treated with FAC chemotherapy alone. Although the overall response rates were similar (76% for FAC‐BCG and 73% for FAC), the duration of remission was of 9 months for FAC and 14 months for FAC‐BCG (p = 0.008). Similarly, survival of responding patients treated with FAC‐BCG was significantly longer (24 months) than that observed in the chemotherapy alone treated group (15 months). There was no difference in survival or duration on study for nonresponders. Analysis of response rates by known prognostic factors was unrewarding. The duration of remission and survival, however, were significantly longer for patients with bone soft tissue involvement than for patients with visceral metastasis. Similarly patients with 1 or 2 metastatic sites survived significantly longer than those with more than 3 organ sites involved (p= 0.02). This chemotherapeutic combination is highly effective in inducing remissions. In addition, nonspecific immunotherapy with BCG appears to prolong duration of remission and survival for responding patients.
AB - One hundred five patients with metastatic breast cancer were treated with 5‐fluorouracil, Adriamycin, cyclophosphamide and BCG (FAC‐BCG). The results were compared to those observed in a group of 44 patients treated with FAC chemotherapy alone. Although the overall response rates were similar (76% for FAC‐BCG and 73% for FAC), the duration of remission was of 9 months for FAC and 14 months for FAC‐BCG (p = 0.008). Similarly, survival of responding patients treated with FAC‐BCG was significantly longer (24 months) than that observed in the chemotherapy alone treated group (15 months). There was no difference in survival or duration on study for nonresponders. Analysis of response rates by known prognostic factors was unrewarding. The duration of remission and survival, however, were significantly longer for patients with bone soft tissue involvement than for patients with visceral metastasis. Similarly patients with 1 or 2 metastatic sites survived significantly longer than those with more than 3 organ sites involved (p= 0.02). This chemotherapeutic combination is highly effective in inducing remissions. In addition, nonspecific immunotherapy with BCG appears to prolong duration of remission and survival for responding patients.
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U2 - 10.1002/1097-0142(197911)44:5<1955::AID-CNCR2820440559>3.0.CO;2-P
DO - 10.1002/1097-0142(197911)44:5<1955::AID-CNCR2820440559>3.0.CO;2-P
M3 - Article
C2 - 387212
AN - SCOPUS:0018616831
SN - 0008-543X
VL - 44
SP - 1955
EP - 1962
JO - Cancer
JF - Cancer
IS - 5
ER -