TY - JOUR
T1 - Communication between genomic and non-genomic signaling events coordinate steroid hormone actions
AU - Wilkenfeld, Sandi R.
AU - Lin, Chenchu
AU - Frigo, Daniel E.
N1 - Funding Information:
We apologize to all the authors whose work we could not cite due to space limitations. We also thank Kelly Kage (UT MD Anderson Cancer Center) for assistance with the figure. This work was supported by NIH grant R01CA184208 (D.E.F.).
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/5
Y1 - 2018/5
N2 - Steroid hormones are lipophilic molecules produced in one cell that can travel great distances within the body to elicit biological effects in another cell. In the canonical pathway, steroid hormone binding to a nuclear receptor (NR), often in the cytoplasm, causes the receptor to undergo a conformational change and translocate to the nucleus, where it interacts with specific sequences of DNA to regulate transcription. In addition to the classical genomic mechanism of action, alternate mechanisms of steroid activity have emerged that involve rapid, non-genomic signaling. The distinction between these two major mechanisms of action lies in the subcellular location of the initiating steroid hormone action. Importantly, the mechanisms of action are not exclusive, in that each can affect the activity of the other. Here, we describe the different types of genomic and non-genomic steroid hormone signaling mechanisms and how they can influence one another to ultimately regulate biology. Further, we discuss the approaches being used to study the non-genomic signaling events and address important caveats to be considered when designing new experiments. Thus, this minireview can serve as an introduction to the diverse signaling mechanisms of steroid hormones and offers initial, experimental guidance to those entering the field.
AB - Steroid hormones are lipophilic molecules produced in one cell that can travel great distances within the body to elicit biological effects in another cell. In the canonical pathway, steroid hormone binding to a nuclear receptor (NR), often in the cytoplasm, causes the receptor to undergo a conformational change and translocate to the nucleus, where it interacts with specific sequences of DNA to regulate transcription. In addition to the classical genomic mechanism of action, alternate mechanisms of steroid activity have emerged that involve rapid, non-genomic signaling. The distinction between these two major mechanisms of action lies in the subcellular location of the initiating steroid hormone action. Importantly, the mechanisms of action are not exclusive, in that each can affect the activity of the other. Here, we describe the different types of genomic and non-genomic steroid hormone signaling mechanisms and how they can influence one another to ultimately regulate biology. Further, we discuss the approaches being used to study the non-genomic signaling events and address important caveats to be considered when designing new experiments. Thus, this minireview can serve as an introduction to the diverse signaling mechanisms of steroid hormones and offers initial, experimental guidance to those entering the field.
KW - Genomic
KW - Non-genomic
KW - Nuclear receptor
KW - Rapid signaling
KW - Steroid hormone
KW - Subcellular localization
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U2 - 10.1016/j.steroids.2017.11.005
DO - 10.1016/j.steroids.2017.11.005
M3 - Article
C2 - 29155216
AN - SCOPUS:85035044799
SN - 0039-128X
VL - 133
SP - 2
EP - 7
JO - Steroids
JF - Steroids
ER -