Comparative Safety, Bioavailability, and Pharmacokinetics of Oral Dexamethasone, 4-mg and 20-mg Tablets, in Healthy Volunteers Under Fasting and Fed Conditions: A Randomized Open-label, 3-way Crossover Study

Qaiser Bashir, Mark Acosta

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Patients with multiple myeloma often receive dexamethasone in combination with novel agent treatment. The current study compared the rate and extent of absorption of a single 20-mg dexamethasone tablet to five 4-mg tablets (total, 20 mg). Both formulations were well-tolerated and bioequivalent under fasting conditions, and dexamethasone 20-mg tablet under fed conditions demonstrated comparable total exposure to fasted conditions.

Original languageEnglish (US)
Pages (from-to)768-773
Number of pages6
JournalClinical Lymphoma, Myeloma and Leukemia
Volume20
Issue number11
DOIs
StatePublished - Nov 2020

Keywords

  • Bioavailability
  • Corticosteroids
  • Dexamethasone
  • Myeloma
  • Oral formulation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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