Comparative survival of Asian and white metastatic castration-resistant prostate cancer men treated with docetaxel

Susan Halabi; Sandipan Dutta; Catherine M. Tangen; Mark Rosenthal; Daniel P. Petrylak; Ian M. Thompson; Kim N. Chi; Johann S. de Bono; John C. Araujo; Christopher Logothetis; Mario A. Eisenberger; David I. Quinn; Karim Fizazi; Michael J. Morris; Celestia S. Higano; Ian F. Tannock; Eric J. Small; William Kevin Kelly

doi:10.1093/JNCICS/PKAA003

Comparative survival of Asian and white metastatic castration-resistant prostate cancer men treated with docetaxel

Susan Halabi, Sandipan Dutta, Catherine M. Tangen, Mark Rosenthal, Daniel P. Petrylak, Ian M. Thompson, Kim N. Chi, Johann S. de Bono, John C. Araujo, Christopher Logothetis, Mario A. Eisenberger, David I. Quinn, Karim Fizazi, Michael J. Morris, Celestia S. Higano, Ian F. Tannock, Eric J. Small, William Kevin Kelly

Genitourinary Medical Oncology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

There are few data regarding disparities in overall survival (OS) between Asian and white men with metastatic castration-resistant prostate cancer (mCRPC). We compared OS of Asian and white mCRPC men treated in phase III clinical trials with docetaxel and prednisone (DP) or a DP-containing regimen. Individual participant data from 8820 men with mCRPC randomly assigned on nine phase III trials to receive DP or a DP-containing regimen were combined. Men enrolled in these trials had a diagnosis of prostate adenocarcinoma. The median overall survival was 18.8 months (95% confidence interval [CI] ¼ 17.4 to 22.1 months) and 21.2 months (95% CI ¼ 20.8 to 21.7 months) for Asian and white men, respectively. The pooled hazard ratio for death for Asian men compared with white men, adjusted for baseline prognostic factors, was 0.95 (95% CI ¼ 0.84 to 1.09), indicating that Asian men were not at increased risk of death. This large analysis showed that Asian men did not have shorter OS duration than white men treated with docetaxel.

Original language	English (US)
Article number	PKAA003
Journal	JNCI Cancer Spectrum
Volume	4
Issue number	2
DOIs	https://doi.org/10.1093/JNCICS/PKAA003
State	Published - 2020

ASJC Scopus subject areas

Oncology
Cancer Research

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Halabi, S., Dutta, S., Tangen, C. M., Rosenthal, M., Petrylak, D. P., Thompson, I. M., Chi, K. N., de Bono, J. S., Araujo, J. C., Logothetis, C., Eisenberger, M. A., Quinn, D. I., Fizazi, K., Morris, M. J., Higano, C. S., Tannock, I. F., Small, E. J., & Kelly, W. K. (2020). Comparative survival of Asian and white metastatic castration-resistant prostate cancer men treated with docetaxel. JNCI Cancer Spectrum, 4(2), Article PKAA003. https://doi.org/10.1093/JNCICS/PKAA003

Halabi, S, Dutta, S, Tangen, CM, Rosenthal, M, Petrylak, DP, Thompson, IM, Chi, KN, de Bono, JS, Araujo, JC , Logothetis, C, Eisenberger, MA, Quinn, DI, Fizazi, K, Morris, MJ, Higano, CS, Tannock, IF, Small, EJ & Kelly, WK 2020, 'Comparative survival of Asian and white metastatic castration-resistant prostate cancer men treated with docetaxel', JNCI Cancer Spectrum, vol. 4, no. 2, PKAA003. https://doi.org/10.1093/JNCICS/PKAA003

@article{08a8a979db654f0c95f99b95c4255da6,

title = "Comparative survival of Asian and white metastatic castration-resistant prostate cancer men treated with docetaxel",

abstract = "There are few data regarding disparities in overall survival (OS) between Asian and white men with metastatic castration-resistant prostate cancer (mCRPC). We compared OS of Asian and white mCRPC men treated in phase III clinical trials with docetaxel and prednisone (DP) or a DP-containing regimen. Individual participant data from 8820 men with mCRPC randomly assigned on nine phase III trials to receive DP or a DP-containing regimen were combined. Men enrolled in these trials had a diagnosis of prostate adenocarcinoma. The median overall survival was 18.8 months (95% confidence interval [CI] ¼ 17.4 to 22.1 months) and 21.2 months (95% CI ¼ 20.8 to 21.7 months) for Asian and white men, respectively. The pooled hazard ratio for death for Asian men compared with white men, adjusted for baseline prognostic factors, was 0.95 (95% CI ¼ 0.84 to 1.09), indicating that Asian men were not at increased risk of death. This large analysis showed that Asian men did not have shorter OS duration than white men treated with docetaxel.",

author = "Susan Halabi and Sandipan Dutta and Tangen, {Catherine M.} and Mark Rosenthal and Petrylak, {Daniel P.} and Thompson, {Ian M.} and Chi, {Kim N.} and {de Bono}, {Johann S.} and Araujo, {John C.} and Christopher Logothetis and Eisenberger, {Mario A.} and Quinn, {David I.} and Karim Fizazi and Morris, {Michael J.} and Higano, {Celestia S.} and Tannock, {Ian F.} and Small, {Eric J.} and Kelly, {William Kevin}",

note = "Funding Information: This research was supported in part by the US Army Medical Research W81XWH-15–1-0467and in part by National Institutes of Health/National Cancer Institute grant awards to SWOG, U10CA180888 and U10CA180819. Publisher Copyright: {\textcopyright} The Author(s) 2020.",

year = "2020",

doi = "10.1093/JNCICS/PKAA003",

language = "English (US)",

volume = "4",

journal = "JNCI Cancer Spectrum",

issn = "2515-5091",

publisher = "Oxford University Press",

number = "2",

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T1 - Comparative survival of Asian and white metastatic castration-resistant prostate cancer men treated with docetaxel

AU - Halabi, Susan

AU - Dutta, Sandipan

AU - Tangen, Catherine M.

AU - Rosenthal, Mark

AU - Petrylak, Daniel P.

AU - Thompson, Ian M.

AU - Chi, Kim N.

AU - de Bono, Johann S.

AU - Araujo, John C.

AU - Logothetis, Christopher

AU - Eisenberger, Mario A.

AU - Quinn, David I.

AU - Fizazi, Karim

AU - Morris, Michael J.

AU - Higano, Celestia S.

AU - Tannock, Ian F.

AU - Small, Eric J.

AU - Kelly, William Kevin

N1 - Funding Information: This research was supported in part by the US Army Medical Research W81XWH-15–1-0467and in part by National Institutes of Health/National Cancer Institute grant awards to SWOG, U10CA180888 and U10CA180819. Publisher Copyright: © The Author(s) 2020.

PY - 2020

Y1 - 2020

N2 - There are few data regarding disparities in overall survival (OS) between Asian and white men with metastatic castration-resistant prostate cancer (mCRPC). We compared OS of Asian and white mCRPC men treated in phase III clinical trials with docetaxel and prednisone (DP) or a DP-containing regimen. Individual participant data from 8820 men with mCRPC randomly assigned on nine phase III trials to receive DP or a DP-containing regimen were combined. Men enrolled in these trials had a diagnosis of prostate adenocarcinoma. The median overall survival was 18.8 months (95% confidence interval [CI] ¼ 17.4 to 22.1 months) and 21.2 months (95% CI ¼ 20.8 to 21.7 months) for Asian and white men, respectively. The pooled hazard ratio for death for Asian men compared with white men, adjusted for baseline prognostic factors, was 0.95 (95% CI ¼ 0.84 to 1.09), indicating that Asian men were not at increased risk of death. This large analysis showed that Asian men did not have shorter OS duration than white men treated with docetaxel.

AB - There are few data regarding disparities in overall survival (OS) between Asian and white men with metastatic castration-resistant prostate cancer (mCRPC). We compared OS of Asian and white mCRPC men treated in phase III clinical trials with docetaxel and prednisone (DP) or a DP-containing regimen. Individual participant data from 8820 men with mCRPC randomly assigned on nine phase III trials to receive DP or a DP-containing regimen were combined. Men enrolled in these trials had a diagnosis of prostate adenocarcinoma. The median overall survival was 18.8 months (95% confidence interval [CI] ¼ 17.4 to 22.1 months) and 21.2 months (95% CI ¼ 20.8 to 21.7 months) for Asian and white men, respectively. The pooled hazard ratio for death for Asian men compared with white men, adjusted for baseline prognostic factors, was 0.95 (95% CI ¼ 0.84 to 1.09), indicating that Asian men were not at increased risk of death. This large analysis showed that Asian men did not have shorter OS duration than white men treated with docetaxel.

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AN - SCOPUS:85085743963

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VL - 4

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ER -

Comparative survival of Asian and white metastatic castration-resistant prostate cancer men treated with docetaxel

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