TY - JOUR
T1 - Comparison of step-and-shoot and continuous-bed-motion PET modes of acquisition for limited-view organ scans
AU - Siman, Wendy
AU - Kappadath, S. Cheenu
N1 - Funding Information:
Research reported in this publication was supported in part by the National Cancer Institute of the National Institutes of Health under award number R01CA138986. The University of Texas MD Anderson Cancer Center is supported in part by the National Cancer Institute through Cancer Center support grant P30CA016672. No other potential conflict of interest relevant to this article was reported.
Publisher Copyright:
© 2017 by the Society of Nuclear Medicine and Molecular Imaging.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Continuous-bed-motion (CBM) acquisition mode has been made commercially available in PET/CT scanners. CBM mode is designed for whole-body imaging, with a long scan length (multiple axial fields of view [aFOVs]) and short acquisition duration (2-3 min/aFOV). PET/CT has recently been used after 90Y-microsphere therapy to quantify 90Y activity distribution in the liver. Here we compared counting efficiencies along the bed-motion direction (z-axis) between CBM and step-and-shoot (SS) acquisition modes for limited-view organ scans, such as 90Y PET/CT liver studies, that have short scan lengths (≤2 aFOVs) and long acquisition durations (10-30 min/aFOV). Methods: The counting efficiencies, that is, analytic sensitivities, in SS mode (single-aFOV and multiple-aFOV scans) and CBM mode were theoretically derived and experimentally validated using a cylindric 68Ge phantom. The sensitivities along the z-axis were compared between the SS and CBMmodes. Results: The analytic and experimental count profiles were in good agreement, validating the analytic models. For fixed scan durations, the overall coincidence counting efficiency in CBM mode was lower (~60%) than those in SS modes, and the maximum sensitivity in CBM mode was 50% or less of that in 1-aFOV SS mode and 100% or less of that in 2-aFOV SS mode. Conclusion: The ability of CBM mode to tailor-fit the PET/CT scan length and local scan duration is not realized in studies with a short scan length (≤30 cm) and long scan duration (20 min/aFOV for the scanner). SS acquisition mode is preferable to CBM mode for limitedview organ and count-starved scans, such as 90Y PET/CT liver scans, because of the higher counting efficiency of SS mode, which leads to better image quality and quantification precision.
AB - Continuous-bed-motion (CBM) acquisition mode has been made commercially available in PET/CT scanners. CBM mode is designed for whole-body imaging, with a long scan length (multiple axial fields of view [aFOVs]) and short acquisition duration (2-3 min/aFOV). PET/CT has recently been used after 90Y-microsphere therapy to quantify 90Y activity distribution in the liver. Here we compared counting efficiencies along the bed-motion direction (z-axis) between CBM and step-and-shoot (SS) acquisition modes for limited-view organ scans, such as 90Y PET/CT liver studies, that have short scan lengths (≤2 aFOVs) and long acquisition durations (10-30 min/aFOV). Methods: The counting efficiencies, that is, analytic sensitivities, in SS mode (single-aFOV and multiple-aFOV scans) and CBM mode were theoretically derived and experimentally validated using a cylindric 68Ge phantom. The sensitivities along the z-axis were compared between the SS and CBMmodes. Results: The analytic and experimental count profiles were in good agreement, validating the analytic models. For fixed scan durations, the overall coincidence counting efficiency in CBM mode was lower (~60%) than those in SS modes, and the maximum sensitivity in CBM mode was 50% or less of that in 1-aFOV SS mode and 100% or less of that in 2-aFOV SS mode. Conclusion: The ability of CBM mode to tailor-fit the PET/CT scan length and local scan duration is not realized in studies with a short scan length (≤30 cm) and long scan duration (20 min/aFOV for the scanner). SS acquisition mode is preferable to CBM mode for limitedview organ and count-starved scans, such as 90Y PET/CT liver scans, because of the higher counting efficiency of SS mode, which leads to better image quality and quantification precision.
KW - 90Y-microsphere
KW - Continuous bed motion
KW - PET/CT
KW - Step and shoot
UR - http://www.scopus.com/inward/record.url?scp=85037047303&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85037047303&partnerID=8YFLogxK
U2 - 10.2967/jnmt.117.195438
DO - 10.2967/jnmt.117.195438
M3 - Article
C2 - 29042468
AN - SCOPUS:85037047303
SN - 0091-4916
VL - 45
SP - 290
EP - 296
JO - Journal of nuclear medicine technology
JF - Journal of nuclear medicine technology
IS - 4
ER -