Comparison of the antialbuminuric effects of L-/N-type and L-type calcium channel blockers in hypertensive patients with diabetes and microalbuminuria: The study of assessment for kidney function by urinary microalbumin in randomized (SAKURA) trial

Katsuayuki Ando, Kenji Ueshima, Sachiko Tanaka, Shinji Kosugi, Tosiya Sato, Hiroaki Matsuoka, Kazuwa Nakao, Toshiro Fujita

    Research output: Contribution to journalArticle

    16 Scopus citations


    Objective: To clarify whether the L-/N-type calcium channel blocker (CCB) cilnidipine is more renoprotective than the L-type CCB amlodipine in patients with early-stage diabetic nephropathy. Methods: In this prospective, multicenter, open-labeled, randomized trial, the antialbuminuric effects of cilnidipine and amlodipine were examined in renin-angiotensin system (RAS) inhibitor- treated patients with hypertension (blood pressure [BP]: 130-180/80-110 mmHg), type 2 diabetes, and microalbuminuria (urinary albumin to creatinine [Cr] ratio [UACR]: 30-300 mg/g). Results: Patients received cilnidipine (n = 179, final dose: 10.27 ± 4.13 mg/day) or amlodipine (n = 186, 4.87 ± 2.08 mg/day) for 12 months. Cilnidipine and amlodipine equally decreased BP. The UACR values for the cilnidipine and amlodipine groups were 111.50 ± 138.97 and 88.29 ± 63.45 mg/g, respectively, before treatment and 107.93 ± 130.23 and 89.07 ± 97.55 mg/g, respectively, after treatment. The groups showed similar changes for the natural logarithm of the UACR, serum Cr, and estimated glomerular filtration rate. Conclusions: Cilnidipine did not offer greater renoprotection than amlodipine in RAS inhibitor- treated hypertensive patients with type 2 diabetes and microalbuminuria.

    Original languageEnglish (US)
    Pages (from-to)1209-1216
    Number of pages8
    JournalInternational journal of medical sciences
    Issue number9
    StatePublished - Jul 30 2013



    • Diabetic nephropathy
    • Hypertension
    • L-/N-type calcium channel blocker
    • Renin-angiotensin system inhibitor
    • Urinary albumin

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this