Comparison of the antialbuminuric effects of L-/N-type and L-type calcium channel blockers in hypertensive patients with diabetes and microalbuminuria: The study of assessment for kidney function by urinary microalbumin in randomized (SAKURA) trial

Katsuayuki Ando, Kenji Ueshima, Sachiko Tanaka, Shinji Kosugi, Tosiya Sato, Hiroaki Matsuoka, Kazuwa Nakao, Toshiro Fujita

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    Abstract

    Objective: To clarify whether the L-/N-type calcium channel blocker (CCB) cilnidipine is more renoprotective than the L-type CCB amlodipine in patients with early-stage diabetic nephropathy. Methods: In this prospective, multicenter, open-labeled, randomized trial, the antialbuminuric effects of cilnidipine and amlodipine were examined in renin-angiotensin system (RAS) inhibitor- treated patients with hypertension (blood pressure [BP]: 130-180/80-110 mmHg), type 2 diabetes, and microalbuminuria (urinary albumin to creatinine [Cr] ratio [UACR]: 30-300 mg/g). Results: Patients received cilnidipine (n = 179, final dose: 10.27 ± 4.13 mg/day) or amlodipine (n = 186, 4.87 ± 2.08 mg/day) for 12 months. Cilnidipine and amlodipine equally decreased BP. The UACR values for the cilnidipine and amlodipine groups were 111.50 ± 138.97 and 88.29 ± 63.45 mg/g, respectively, before treatment and 107.93 ± 130.23 and 89.07 ± 97.55 mg/g, respectively, after treatment. The groups showed similar changes for the natural logarithm of the UACR, serum Cr, and estimated glomerular filtration rate. Conclusions: Cilnidipine did not offer greater renoprotection than amlodipine in RAS inhibitor- treated hypertensive patients with type 2 diabetes and microalbuminuria.

    Original languageEnglish (US)
    Pages (from-to)1209-1216
    Number of pages8
    JournalInternational journal of medical sciences
    Volume10
    Issue number9
    DOIs
    StatePublished - Jul 30 2013

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    Keywords

    • Diabetic nephropathy
    • Hypertension
    • L-/N-type calcium channel blocker
    • Renin-angiotensin system inhibitor
    • Urinary albumin

    ASJC Scopus subject areas

    • Medicine(all)

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