Comparison of the prognostic value of inflammation-based scores in early recurrent hepatocellular carcinoma after hepatectomy

Chenwei Wang, Wei He, Yichuan Yuan, Yuanping Zhang, Kai Li, Ruhai Zou, Yadi Liao, Wenwu Liu, Zhiwen Yang, Dinglan Zuo, Jiliang Qiu, Yun Zheng, Binkui Li, Yunfei Yuan

Research output: Contribution to journalArticle

Abstract

Background & Aims: Inflammation-based prognostic scores, such as the Glasgow Prognostic Score (GPS), modified Glasgow Prognostic Score (mGPS), Prognostic Index (PI), Prognostic Nutritional Index (PNI), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and systemic immune-inflammation index (SII), are correlated with the survival of hepatocellular carcinoma (HCC) patients, while remain unclear for recurrent HCC. This study aimed to compare the prognostic value of inflammation-based prognostic scores for post-recurrence survival (PRS) in patients with early recurrent HCC (ErHCC, within 2 years after hepatectomy). Methods: A total of 580 patients with ErHCC were enrolled retrospectively. The association between the independent baseline and the time-dependent variables and PRS was evaluated by cox regression. The prediction accuracy of the inflammation-based prognostic scores was assessed by time-dependent receiver operating characteristic (ROC) and Harrell's concordance index (C-index) analyses. Results: The GPS, mGPS, PI, PNI, NLR, PLR, LMR and SII were all related to the PRS of ErHCC patients, while only the SII (P <.001) remained an independent predictor for PRS in multivariate analysis (hazard ratio: 1.92, 95% confidence interval: 1.33-2.79). Both the C-index of the SII (0.65) and the areas under the ROC curves showed that the SII score was superior to the other inflammation-based prognostic scores for predicting the PRS of ErHCC patients. Conclusions: The SII is a useful prognostic indicator for PRS in patients with ErHCC after hepatectomy and is superior to the other inflammation-based prognostic scores in terms of prognostic ability.

Original languageEnglish (US)
Pages (from-to)229-239
Number of pages11
JournalLiver International
Volume40
Issue number1
DOIs
StatePublished - Jan 1 2020

Fingerprint

Hepatectomy
Hepatocellular Carcinoma
Inflammation
Lymphocytes
Survival
Recurrence
Nutrition Assessment
ROC Curve
Monocytes
Neutrophils
Blood Platelets
Multivariate Analysis
Confidence Intervals

Keywords

  • early recurrent hepatocellular carcinoma
  • inflammation-based prognostic score
  • prognosis predictor
  • systemic immune-inflammation index

ASJC Scopus subject areas

  • Hepatology

Cite this

Comparison of the prognostic value of inflammation-based scores in early recurrent hepatocellular carcinoma after hepatectomy. / Wang, Chenwei; He, Wei; Yuan, Yichuan; Zhang, Yuanping; Li, Kai; Zou, Ruhai; Liao, Yadi; Liu, Wenwu; Yang, Zhiwen; Zuo, Dinglan; Qiu, Jiliang; Zheng, Yun; Li, Binkui; Yuan, Yunfei.

In: Liver International, Vol. 40, No. 1, 01.01.2020, p. 229-239.

Research output: Contribution to journalArticle

Wang, C, He, W, Yuan, Y, Zhang, Y, Li, K, Zou, R, Liao, Y, Liu, W, Yang, Z, Zuo, D, Qiu, J, Zheng, Y, Li, B & Yuan, Y 2020, 'Comparison of the prognostic value of inflammation-based scores in early recurrent hepatocellular carcinoma after hepatectomy', Liver International, vol. 40, no. 1, pp. 229-239. https://doi.org/10.1111/liv.14281
Wang, Chenwei ; He, Wei ; Yuan, Yichuan ; Zhang, Yuanping ; Li, Kai ; Zou, Ruhai ; Liao, Yadi ; Liu, Wenwu ; Yang, Zhiwen ; Zuo, Dinglan ; Qiu, Jiliang ; Zheng, Yun ; Li, Binkui ; Yuan, Yunfei. / Comparison of the prognostic value of inflammation-based scores in early recurrent hepatocellular carcinoma after hepatectomy. In: Liver International. 2020 ; Vol. 40, No. 1. pp. 229-239.
@article{875923d33d464cbc87fdb9c81927f0b2,
title = "Comparison of the prognostic value of inflammation-based scores in early recurrent hepatocellular carcinoma after hepatectomy",
abstract = "Background & Aims: Inflammation-based prognostic scores, such as the Glasgow Prognostic Score (GPS), modified Glasgow Prognostic Score (mGPS), Prognostic Index (PI), Prognostic Nutritional Index (PNI), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and systemic immune-inflammation index (SII), are correlated with the survival of hepatocellular carcinoma (HCC) patients, while remain unclear for recurrent HCC. This study aimed to compare the prognostic value of inflammation-based prognostic scores for post-recurrence survival (PRS) in patients with early recurrent HCC (ErHCC, within 2 years after hepatectomy). Methods: A total of 580 patients with ErHCC were enrolled retrospectively. The association between the independent baseline and the time-dependent variables and PRS was evaluated by cox regression. The prediction accuracy of the inflammation-based prognostic scores was assessed by time-dependent receiver operating characteristic (ROC) and Harrell's concordance index (C-index) analyses. Results: The GPS, mGPS, PI, PNI, NLR, PLR, LMR and SII were all related to the PRS of ErHCC patients, while only the SII (P <.001) remained an independent predictor for PRS in multivariate analysis (hazard ratio: 1.92, 95{\%} confidence interval: 1.33-2.79). Both the C-index of the SII (0.65) and the areas under the ROC curves showed that the SII score was superior to the other inflammation-based prognostic scores for predicting the PRS of ErHCC patients. Conclusions: The SII is a useful prognostic indicator for PRS in patients with ErHCC after hepatectomy and is superior to the other inflammation-based prognostic scores in terms of prognostic ability.",
keywords = "early recurrent hepatocellular carcinoma, inflammation-based prognostic score, prognosis predictor, systemic immune-inflammation index",
author = "Chenwei Wang and Wei He and Yichuan Yuan and Yuanping Zhang and Kai Li and Ruhai Zou and Yadi Liao and Wenwu Liu and Zhiwen Yang and Dinglan Zuo and Jiliang Qiu and Yun Zheng and Binkui Li and Yunfei Yuan",
year = "2020",
month = "1",
day = "1",
doi = "10.1111/liv.14281",
language = "English (US)",
volume = "40",
pages = "229--239",
journal = "Liver International",
issn = "1478-3223",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Comparison of the prognostic value of inflammation-based scores in early recurrent hepatocellular carcinoma after hepatectomy

AU - Wang, Chenwei

AU - He, Wei

AU - Yuan, Yichuan

AU - Zhang, Yuanping

AU - Li, Kai

AU - Zou, Ruhai

AU - Liao, Yadi

AU - Liu, Wenwu

AU - Yang, Zhiwen

AU - Zuo, Dinglan

AU - Qiu, Jiliang

AU - Zheng, Yun

AU - Li, Binkui

AU - Yuan, Yunfei

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Background & Aims: Inflammation-based prognostic scores, such as the Glasgow Prognostic Score (GPS), modified Glasgow Prognostic Score (mGPS), Prognostic Index (PI), Prognostic Nutritional Index (PNI), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and systemic immune-inflammation index (SII), are correlated with the survival of hepatocellular carcinoma (HCC) patients, while remain unclear for recurrent HCC. This study aimed to compare the prognostic value of inflammation-based prognostic scores for post-recurrence survival (PRS) in patients with early recurrent HCC (ErHCC, within 2 years after hepatectomy). Methods: A total of 580 patients with ErHCC were enrolled retrospectively. The association between the independent baseline and the time-dependent variables and PRS was evaluated by cox regression. The prediction accuracy of the inflammation-based prognostic scores was assessed by time-dependent receiver operating characteristic (ROC) and Harrell's concordance index (C-index) analyses. Results: The GPS, mGPS, PI, PNI, NLR, PLR, LMR and SII were all related to the PRS of ErHCC patients, while only the SII (P <.001) remained an independent predictor for PRS in multivariate analysis (hazard ratio: 1.92, 95% confidence interval: 1.33-2.79). Both the C-index of the SII (0.65) and the areas under the ROC curves showed that the SII score was superior to the other inflammation-based prognostic scores for predicting the PRS of ErHCC patients. Conclusions: The SII is a useful prognostic indicator for PRS in patients with ErHCC after hepatectomy and is superior to the other inflammation-based prognostic scores in terms of prognostic ability.

AB - Background & Aims: Inflammation-based prognostic scores, such as the Glasgow Prognostic Score (GPS), modified Glasgow Prognostic Score (mGPS), Prognostic Index (PI), Prognostic Nutritional Index (PNI), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and systemic immune-inflammation index (SII), are correlated with the survival of hepatocellular carcinoma (HCC) patients, while remain unclear for recurrent HCC. This study aimed to compare the prognostic value of inflammation-based prognostic scores for post-recurrence survival (PRS) in patients with early recurrent HCC (ErHCC, within 2 years after hepatectomy). Methods: A total of 580 patients with ErHCC were enrolled retrospectively. The association between the independent baseline and the time-dependent variables and PRS was evaluated by cox regression. The prediction accuracy of the inflammation-based prognostic scores was assessed by time-dependent receiver operating characteristic (ROC) and Harrell's concordance index (C-index) analyses. Results: The GPS, mGPS, PI, PNI, NLR, PLR, LMR and SII were all related to the PRS of ErHCC patients, while only the SII (P <.001) remained an independent predictor for PRS in multivariate analysis (hazard ratio: 1.92, 95% confidence interval: 1.33-2.79). Both the C-index of the SII (0.65) and the areas under the ROC curves showed that the SII score was superior to the other inflammation-based prognostic scores for predicting the PRS of ErHCC patients. Conclusions: The SII is a useful prognostic indicator for PRS in patients with ErHCC after hepatectomy and is superior to the other inflammation-based prognostic scores in terms of prognostic ability.

KW - early recurrent hepatocellular carcinoma

KW - inflammation-based prognostic score

KW - prognosis predictor

KW - systemic immune-inflammation index

UR - http://www.scopus.com/inward/record.url?scp=85075714912&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075714912&partnerID=8YFLogxK

U2 - 10.1111/liv.14281

DO - 10.1111/liv.14281

M3 - Article

C2 - 31652394

AN - SCOPUS:85075714912

VL - 40

SP - 229

EP - 239

JO - Liver International

JF - Liver International

SN - 1478-3223

IS - 1

ER -