Complications of Immunosuppressive Therapy in Solid Organ Transplantation

Venkata Katabathina; Christine O. Menias; Perry Pickhardt; Meghan Lubner; Srinivasa R. Prasad

doi:10.1016/j.rcl.2015.09.009

Complications of Immunosuppressive Therapy in Solid Organ Transplantation

Venkata Katabathina, Christine O. Menias, Perry Pickhardt, Meghan Lubner, Srinivasa R. Prasad

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

Abstract

Availability of novel immunosuppressive drugs is the most important factor responsible for significant improvement in long-term graft survival rates after solid organ transplantation. However, chronic immunosuppression predisposes patients to a myriad of potentially life-threatening complications. In addition to drug-related adverse effects, transplant recipients are at increased risk of developing opportunistic microbial infections and a spectrum of unique cancers, many of which are caused by oncogenic viruses. Cross-sectional imaging studies play a crucial role in the timely diagnosis and management of post-transplant infections and malignancies.

Original language	English (US)
Pages (from-to)	303-319
Number of pages	17
Journal	Radiologic Clinics of North America
Volume	54
Issue number	2
DOIs	https://doi.org/10.1016/j.rcl.2015.09.009
State	Published - Mar 1 2016

Keywords

Complications
Computed tomography
Immunosuppression
Infections
MR imaging
Malignancy
Posttransplant lymphoproliferative disorder (PTLD)
Transplantation

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1016/j.rcl.2015.09.009

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title = "Complications of Immunosuppressive Therapy in Solid Organ Transplantation",

abstract = "Availability of novel immunosuppressive drugs is the most important factor responsible for significant improvement in long-term graft survival rates after solid organ transplantation. However, chronic immunosuppression predisposes patients to a myriad of potentially life-threatening complications. In addition to drug-related adverse effects, transplant recipients are at increased risk of developing opportunistic microbial infections and a spectrum of unique cancers, many of which are caused by oncogenic viruses. Cross-sectional imaging studies play a crucial role in the timely diagnosis and management of post-transplant infections and malignancies.",

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AU - Katabathina, Venkata

AU - Menias, Christine O.

AU - Pickhardt, Perry

AU - Lubner, Meghan

AU - Prasad, Srinivasa R.

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AB - Availability of novel immunosuppressive drugs is the most important factor responsible for significant improvement in long-term graft survival rates after solid organ transplantation. However, chronic immunosuppression predisposes patients to a myriad of potentially life-threatening complications. In addition to drug-related adverse effects, transplant recipients are at increased risk of developing opportunistic microbial infections and a spectrum of unique cancers, many of which are caused by oncogenic viruses. Cross-sectional imaging studies play a crucial role in the timely diagnosis and management of post-transplant infections and malignancies.

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KW - Computed tomography

KW - Immunosuppression

KW - Infections

KW - MR imaging

KW - Malignancy

KW - Posttransplant lymphoproliferative disorder (PTLD)

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Complications of Immunosuppressive Therapy in Solid Organ Transplantation

Abstract

Keywords

ASJC Scopus subject areas

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