Abstract
Human pluripotent stem cells (PSCs) provide a promising resource to produce immune cells for adoptive cellular immunotherapy to better treat and potentially cure otherwise lethal cancers. Cytotoxic T cells and natural killer (NK) cells can now be routinely produced from human PSCs. These PSC-derived lymphocytes have phenotype and function similar to primary lymphocytes isolated from peripheral blood. PSC-derived T and NK cells have advantages compared with primary immune cells, as they can be precisely engineered to introduce improved anti-tumor activity and produced in essentially unlimited numbers. Stem Cells 2018;36:134–145.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 134-145 |
| Number of pages | 12 |
| Journal | Stem Cells |
| Volume | 36 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2018 |
| Externally published | Yes |
Keywords
- Adoptive cell therapy
- Cancer immunotherapy
- Human pluripotent stem cell
- Natural Killer cell
- Natural Killer T cell
- T cell
ASJC Scopus subject areas
- Molecular Medicine
- Developmental Biology
- Cell Biology
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