Abstract
Epidermodysplasia verruciformis (EDV) is a rare genodermatosis that predisposes individuals to persistent infection with β-human papillomavirus (HPV) genotypes. The term EDV acanthoma may be applied to lesions with incidental findings of EDV-defining histopathological features without clinical signs of EDV. We report a case of HPV-14- and -21-positive EDV acanthoma arising in association with condyloma in a female patient with a history of low-grade squamous intraepithelial lesion of the cervix positive for high-risk HPV (non-16/18), chronic kidney disease, and systemic lupus erythematosus. The patient had no family or personal history of EDV, but the patient was on immunosuppressive therapy with mycophenolate mofetil and prednisone. A biopsy specimen from one of the perianal lesions revealed histopathologic changes consistent with EDV in the setting of condyloma. Molecular testing showed HPV-14 and -21, which supported the coexistence of condyloma with EDV acanthoma.
Original language | English (US) |
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Pages (from-to) | 47-50 |
Number of pages | 4 |
Journal | Journal of cutaneous pathology |
Volume | 50 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2023 |
Keywords
- acanthoma
- condyloma
- epidermodysplasia verruciformis
- human papillomavirus-14 and -21
- immunocompromised host
- squamous cell carcinoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
- Dermatology