Constituents from the leaves of Phellodendron amurense var. wilsonii and their bioactivity

Tian Shung Wu, Meei Yu Hsu, Ping Chung Kuo, B. Sreenivasulu, A. G. Damu, Chung Ren Su, Chia Ying Li, Hsien Chang Chang

    Research output: Contribution to journalArticle

    35 Scopus citations

    Abstract

    Two new dihydroflavonols, phellodensin-A (1) and phellodensin-C (2); three new coumarins, phellodenol-A (3), phellodenol-B (4), and phellodenol-C (5); one new chlorophyll, phellophyll-a (6); and one new phenyllactate, (2R)-sodium 3-phenyllactate (7), in addition to 35 known compounds have been isolated from the leaves of Phellodendron amurense var. wilsonii. The structures of the new compounds were established based on 1D, 2D NMR and mass spectral analyses. The stereochemistry at the C-2, C-3, and C-2″ positions of new dihydroflavonol 1 was determined by CD spectroscopy. The known compounds were identified by comparison with authentic samples. The antioxidant and antityrosinase activities were also described.

    Original languageEnglish (US)
    Pages (from-to)1207-1211
    Number of pages5
    JournalJournal of Natural Products
    Volume66
    Issue number9
    StatePublished - Sep 1 2003

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Molecular Medicine
    • Pharmacology
    • Pharmaceutical Science
    • Drug Discovery
    • Complementary and alternative medicine
    • Organic Chemistry

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    Wu, T. S., Hsu, M. Y., Kuo, P. C., Sreenivasulu, B., Damu, A. G., Su, C. R., Li, C. Y., & Chang, H. C. (2003). Constituents from the leaves of Phellodendron amurense var. wilsonii and their bioactivity. Journal of Natural Products, 66(9), 1207-1211.