Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Mireia Obón-Santacana, Leila Luján-Barroso, Heinz Freisling, Sabine Naudin, Marie Christine Boutron-Ruault, Francesca Romana Mancini, Vinciane Rebours, Tilman Kühn, Verena Katzke, Heiner Boeing, Anne Tjønneland, Anja Olsen, Kim Overvad, Cristina Lasheras, Miguel Rodríguez-Barranco, Pilar Amiano, Carmen Santiuste, Eva Ardanaz, Kay Thee Khaw, Nicholas J. WarehamJulie A. Schmidt, Dagfinn Aune, Antonia Trichopoulou, Paschalis Thriskos, Eleni Peppa, Giovanna Masala, Sara Grioni, Rosario Tumino, Salvatore Panico, Bas Bueno-de-Mesquita, Veronica Sciannameo, Roel Vermeulen, Emily Sonestedt, Malin Sund, Elisabete Weiderpass, Guri Skeie, Carlos A. González, Elio Riboli, Eric J. Duell

Research output: Contribution to journalArticle

Abstract

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

Original languageEnglish (US)
Pages (from-to)76-84
Number of pages9
JournalInternational Journal of Cancer
Volume146
Issue number1
DOIs
StatePublished - Jan 1 2020

Fingerprint

Nuts
Seeds
Adenocarcinoma
Neoplasms
Confidence Intervals
Pancreatic Neoplasms
Proportional Hazards Models
Epidemiologic Studies

Keywords

  • EPIC
  • diet
  • intake
  • nuts
  • pancreatic cancer
  • prospective cohort study
  • seeds

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M. C., Mancini, F. R., ... Duell, E. J. (2020). Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 146(1), 76-84. https://doi.org/10.1002/ijc.32415

Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition. / Obón-Santacana, Mireia; Luján-Barroso, Leila; Freisling, Heinz; Naudin, Sabine; Boutron-Ruault, Marie Christine; Mancini, Francesca Romana; Rebours, Vinciane; Kühn, Tilman; Katzke, Verena; Boeing, Heiner; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Lasheras, Cristina; Rodríguez-Barranco, Miguel; Amiano, Pilar; Santiuste, Carmen; Ardanaz, Eva; Khaw, Kay Thee; Wareham, Nicholas J.; Schmidt, Julie A.; Aune, Dagfinn; Trichopoulou, Antonia; Thriskos, Paschalis; Peppa, Eleni; Masala, Giovanna; Grioni, Sara; Tumino, Rosario; Panico, Salvatore; Bueno-de-Mesquita, Bas; Sciannameo, Veronica; Vermeulen, Roel; Sonestedt, Emily; Sund, Malin; Weiderpass, Elisabete; Skeie, Guri; González, Carlos A.; Riboli, Elio; Duell, Eric J.

In: International Journal of Cancer, Vol. 146, No. 1, 01.01.2020, p. 76-84.

Research output: Contribution to journalArticle

Obón-Santacana, M, Luján-Barroso, L, Freisling, H, Naudin, S, Boutron-Ruault, MC, Mancini, FR, Rebours, V, Kühn, T, Katzke, V, Boeing, H, Tjønneland, A, Olsen, A, Overvad, K, Lasheras, C, Rodríguez-Barranco, M, Amiano, P, Santiuste, C, Ardanaz, E, Khaw, KT, Wareham, NJ, Schmidt, JA, Aune, D, Trichopoulou, A, Thriskos, P, Peppa, E, Masala, G, Grioni, S, Tumino, R, Panico, S, Bueno-de-Mesquita, B, Sciannameo, V, Vermeulen, R, Sonestedt, E, Sund, M, Weiderpass, E, Skeie, G, González, CA, Riboli, E & Duell, EJ 2020, 'Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition', International Journal of Cancer, vol. 146, no. 1, pp. 76-84. https://doi.org/10.1002/ijc.32415
Obón-Santacana, Mireia ; Luján-Barroso, Leila ; Freisling, Heinz ; Naudin, Sabine ; Boutron-Ruault, Marie Christine ; Mancini, Francesca Romana ; Rebours, Vinciane ; Kühn, Tilman ; Katzke, Verena ; Boeing, Heiner ; Tjønneland, Anne ; Olsen, Anja ; Overvad, Kim ; Lasheras, Cristina ; Rodríguez-Barranco, Miguel ; Amiano, Pilar ; Santiuste, Carmen ; Ardanaz, Eva ; Khaw, Kay Thee ; Wareham, Nicholas J. ; Schmidt, Julie A. ; Aune, Dagfinn ; Trichopoulou, Antonia ; Thriskos, Paschalis ; Peppa, Eleni ; Masala, Giovanna ; Grioni, Sara ; Tumino, Rosario ; Panico, Salvatore ; Bueno-de-Mesquita, Bas ; Sciannameo, Veronica ; Vermeulen, Roel ; Sonestedt, Emily ; Sund, Malin ; Weiderpass, Elisabete ; Skeie, Guri ; González, Carlos A. ; Riboli, Elio ; Duell, Eric J. / Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition. In: International Journal of Cancer. 2020 ; Vol. 146, No. 1. pp. 76-84.
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abstract = "Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95{\%} confidence intervals (95{\%} CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95{\%} CI, 0.72–1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.",
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